1.围术期神经认知功能紊乱；PerioperativeNeurocognitive Disorder

2.脓毒症相关认知功能障碍；Sepsis-relatedCognitiveDysfunction

1. 中华医学会麻醉学分会青年学组，委员（Member of Youth group, Chinese Society of Anesthesiology）

2. 中国心胸血管麻醉学会创新与推广分会，常务委员（Standing Committee Member of Committee of Innovation and Promotion, Chinese Society of Cardiothoracic and Vascular Anesthesiology）

3. 中国心胸血管麻醉学会人工智能麻醉分会，委员（Member of Artificial Intelligence Anesthesia Committee, Chinese Society of Cardiothoracic and Vascular Anesthesiology）

4. 中国医疗保健国际交流促进会区域阻滞与疼痛医学分会，委员（Member of Regional Blocking and Pain Branch, China International Exchange and Promote Association for Medical and Healthcare)

5. 中国医疗保健国际交流促进会麻醉围术期医学分会，委员(Member of Perioperative Medicine Branch of Anesthesia ,China International Exchange and Promotive Association for Medical and Healthcare)

6. 中国超声工程学会麻醉与疼痛超声委员会，委员（Member of Committee on Ultrasound of Anesthesia and Pain, Chinese Association of Ultrasound in Medicine and Engineering)

7. 中国医学模拟教学联盟气道管理专业委员会，委员 (Member of Airway Management Professional Committee, Chinese Medical Stimulation Teaching Alliance)

8. 中华医学会麻醉学分会创新诊疗学组，委员（Member of Innovative diagnosis and Treatment Group, Chinese Society of Anesthesiology）

9. 中国非公立医疗机构协会麻醉专业委员会，委员（member of Anesthesia Committee, Chinese Non-government Medical Institutions Assosiation）

10. 上海市医师协会麻醉科医师分会，委员（member of the Anesthesiologist Branch of Shanghai Medical Doctor Association）

11. 上海中医药学会围术期医学分会，委员（member of Perioperative Medicine Committee，Shanghai Association of Chinese Medicine）

12. 上海市研究型医院学会麻醉与围术期专业委员会，委员（member of Anesthesiology and Perioperative Medicine Committee of Shanghai Research Hospital Society）

哈佛医学院附属麻省总院访问学者，同济大学附属上海市第四人民医院麻醉与围术期医学科主任（国家临床重点专科、全国卫生健康系统优秀集体），上海市优秀学术带头人（青年），上海市东方英才（青年）、“中国好医生”、首届“上海好医生”、上海市“银蛇奖”三等奖。主要研究方向是老年麻醉与围术期管理和脑保护，主持国家自然科学基金等项目18项，参与国自然重大项目、国自然国际合作重点项目等6项，主持科研总经费496.5万元。以通讯/第一作者在国际知名期刊BJA，Angew. Chem. Int. Ed等发表SCI论文34篇（其中JCR 1区21篇，JCR 2区10篇，单篇最高IF 16.6，总IF 179.999），授权发明专利1项、实用新型专利5项。Anesthesiology and Perioperative Science学术编委、教育部学位论文评审专家。获得同济大学医学院优秀教师，培养博士后/博硕士研究生21人次，其中1人获得上海市优秀毕业生。

近年主持的主要科研项目及人才计划：

1.上海市医苑新星杰出青年医学人才（Shanghai Medical Park New star outstanding young medical talents）：组蛋白H3K18乳酸化影响小胶质细胞更替在术后认知功能障碍中作用机制研究， 80万，20244Z0007，2024/01/01-2026/12/31，在研，主持。

2.虹口区卫健委临床重点扶持专科建设：重症医学科 建设项目（Hongkou District Health Commission clinical key support specialty construction: intensive care medicine construction project），60万，HKLCFC202405， 2024/01/01-2026/12/31，在研，主持。

3.上海市东方英才计划青年项目（Shanghai Oriental Talents Program youth project）：基于能量代谢探究老年患者PND的神经机制 ，30万，23DF131401， 2024/01/01-2026/12/31，在研，主持。

4.学科助推计划重点项目（Subject Enhancement Programme of Shanghai Fourth People’s Hospital ）：H3K56乳酸化上调PD-1影响小胶质细胞更替在POCD中的机制研究， 30万元，SY-XKZT-2023-1001，2024/03/01-2027/02/28，在研，主持。

5.上海市优秀学术带头人（Shanghai excellent academic leader of Shanghai Science and Technology Commission）：基于海马小胶质细胞蛋白乳酸化修饰探究术后谵妄的发生机制，40万，23XD1422900，2023/05/01-2026/04/30，在研，主持。

6.国家自然科学基金面上项目（National Natural Scientific Foundation of China）：小胶质细胞MD2调控突触稳定性介导术后认知功能障碍的机制研究，52万，82271223，2023/01/01-2026/12/31，在研，主持。

7.上海市自然科学基金项目（Natural Science Foundation of Shanghai）：能量相关CircRNA-Sobp/miR-672-3p/ATPIF1信号轴调控线粒体凋亡在七氟烷诱导术后认知功能障碍中的作用及机制研究，20万，20ZR1442900，2020/07/01-2023/06/30，已结题，主持。

8.2021年度上海市第四人民医院科研启动经费（Scientific Research Start-up Fund from Shanghai Fourth People’s Hospital）：NMDAR/FOXO3A/ circRNA- Sobp通路在吸入麻醉药麻醉作用及术后认知功能障碍中的共有机制研究，sykyqd01901，2021.02- 2027.01，100万，在研，主持。

9.2021年度上海市第四人民医院学科助推计划（新技术重点项目）（Subject Enhancement Programme of Shanghai Fourth People’s Hospital ）：椎旁神经阻滞复合骶管麻醉在经皮肾镜激光碎石中的应用，2021.10.01-2023.09.30，SY-XKZT-2021-2001，10万，已结题，主持。

10.国家自然基金青年项目（Youth Project of National Natural Scientific Foundation of China )：ATPIF1/ATP合酶在异氟烷致秀丽线虫全身损伤中的机制研究，20万，81600921，2017/01-2019/12, 已结题，主持。

11.上海市自然科学基金项目（Natural Science Foundation of Shanghai）：ATP合酶c-亚基环解耦联通道介导吸入麻醉药神经毒性作用的分子机制，20万，16ZR1426400，2016/07/01-2019/06/30，已结题，主持。

二、近两年发表的主要论文：

 1.Jiang Li#, Yayun Shi#, Chenyang Qi#, Bowen Zhang, Xiwen Xing, Yuliang Li*, Tongdan Chen, Xingnuo Mao, Zhijun Zuo, Xiaoli Zhao, Zhenghui Pan, Libo Li, Xiaowei Yang* and Cheng Li*. Charging Metal-Organic Framework Membranes by Incorporating Crown Ethers to Capture Cations for Ion Sieving. Angew Chem Int Ed Engl. 2023 Oct 2;62(40):e202309918.doi: 10.1002/anie.202309918. Epub 2023 Aug 24. (通讯作者，IF: 16.1，JCR 1区，VIP论文) 

2.Xiaoru Sun#, Tao Chang#, Yaru Xu , Qi Jing , Silu Cao , Li Tian*, Cheng Li*. Effects of different doses of cisatracurium on intraoperative nerve monitoring in thyroid surgery: a randomised controlled trial. Br J Anaesth. 2021 Aug;127(2):e67-e69. (通讯作者, IF:11.719, JCR 1区)

3.Xiaoru Sun#, HuitongRuan# *, Qidong Liu, Silu Cao, Qi Jing, Yaru Xu, LizeXiong*, Wenguo Cui*, Cheng Li*.Targeted regulation of neuroinflammation via nanobiosignaler for repairing the central nerve injuries. Nano Res. 25 Nov. 2022, online, DOI：https://doi.org/10.1007/s12274-022-5143-3.(通讯作者，IF: 9.9， JCR 1区) 

4.Miaomiao Fei#, Hui Zhang#,  Fanbing Meng,  Guanghui An, Jinxuan Tang, Jianbin Tong, Lize Xiong*, Qidong Liu*, Cheng Li*. Enhanced lactate accumulation upregulates PD-L1expression to delay neutrophil apoptosis in sepsis. VIEW. 2023;20230053. https://doi.org/10.1002/VIW.20230053 (通讯作者，IF:9.7，JCR 1区) 

5.Yuxi Zhang#，Chaoran Chen#，Miao Su，Junxia Wang，Cheng Li*，Xianzhu Yang*. Hydrophobization of ribonucleic acids for facile systemic delivery and multifaceted cancer immunotherapy. Nano Letters. 2024. (共通讯作者，IF: 9.6，JCR 1区) 

6.Qidong Liu#,Huitong Ruan#,Zhihao Sheng#,Xiaoru Sun,Siguang Li*,Wenguo Cui* and Cheng Li*. Nanoantidote for repression of acidosis pH promoting COVID-19 infection. View 2022. First published: 01 May 2022; https://doi.org/ 10.1002/VIW.20220004(通讯作者，IF:8.6，JCR 1区) 

7.Silu Cao#, Jinxuan Tang #, Miaomiao Fei#, Qi Jing, Fanbing Meng, Meixian Zhang, Qidong Liu*, Hui Zhang*, Cheng Li*. Identification of potential hubgenes linked to immune andmetabolic alterations inpostoperative systemicinflammatory dysregulation. Front.Immunol. 2023,  DOI: 10.3389/fimmu. 2023.1238774 (通讯作者，IF: 6.8，JCR 1区) 

8.QiJing#, Jian Song, Guanghui An, Enzhao Zhu, Zisheng Ai, Lize Xiong, Cheng Li*. Effective early strategy to prevent olfactory and gustatory dysfunction in COVID-19: A randomized controlled trial. QJM: An International Journal of Medicine, hcad262, https://doi.org/10.1093/qjmed/hcad262. (通讯作者，IF: 6.4，JCR 1区) 

9.Yaru Xu#, Ge Gao#, Xiaoru Sun, Qidong Liu*,Cheng Li*. ATPase Inhibitory Factor 1 is critical for regulating sevoflurane-induced microglial inflammatory responses and caspase-3 activation. Front. Cell. Neurosci.15 December  2021.https://doi.org/10.3389/fncel.2021.770666（通讯作者，IF:6.147，JCR 2区） 

10.Hui Zhang#, Silu Cao#, Yaru Xu, Xiaoru Sun, Miaomiao Fei, Qi Jing, Xiaodong Xu,Jinxuan Tang, Bing Niu* and Cheng Li*. Landscape of Immune Compartment in Entorhinal Cortex of Alzheimerʼs Disease. Front. Pharmacol., 28 September 2022Sec.Neuropharmacologyhttps://doi.org/10.3389/fphar.2022.941656.(通讯作者，IF:5.6，JCR 1区) 

11.Silu Cao#, Yiling Wu#, Zilong Gao#, Jinxuan Tang, Lize Xiong, Ji Hu*, Cheng Li*. Automated phenotyping of postoperative delirium-like behaviour in mice reveals the therapeutic efficacy of dexmedetomidine. Commun Biol 6, 807 (2023). https://doi.org/10.1038/s42003-023-05149-7 (通讯作者，IF: 5.2，JCR 1区) 

12.Lingling Zhang#, Tao Chang#, Yaru Xu, Qi Jing, Xuan Zhao* and Cheng Li*. Epidural anesthesia with low concentration ropivacaine and sufentanil for percutaneous transforaminal endoscopic discectomy: a randomized controlled trial.Front Med (Lausanne). 2020 Jul 31;7:362.(通讯作者，IF:5.091，JCR 1区) 

13.ShaochengWang#, ChaoliHu#, TingtingZhang, Xuan Zhao*,Cheng Li*.Comparison of cricothyroid membrane puncture anesthesia and topical anesthesia for awake fiberoptic intubation: a double-blinded randomized controlled trial.Front Med (Lausanne). 2021 Nov 16; 8: 743009.(通讯作者，IF:5.058，JCR 1区) 

14.Jian Song#, Qi Jing#, Enzhao Zhu#, Qidong Liu, Miaomiao Fei, Hui Zhang, Guanghui An, Silu Cao, Jinxuan Tang, Guanghui Xu, Yi Liu, Zisheng Ai, Yingna Tao*, Cheng Li*, Lize Xiong*. Alterations in smell or taste in individuals infected with SARS-CoV-2 during periods of Omicron variant dominance. International Journal of Infectious Diseases.International Journal of Infectious Diseases 128 (2023) 278–284. Published: January 15, 2023, DOI:https://doi.org/10.1016/j.ijid.2023.01.017 (共通讯作者，IF: 4.8， JCR 1区) 

15.Qi Jing , Lize Xiong* , Cheng Li*, The prevalence of olfactory dysfunction with Omicron has decreased in Asia, similar to Western countries – Author’s reply, International Journal of Infectious Diseases (2023), doi: https://doi.org/10.1016/j.ijid.2023.03.041. (通讯作者，IF: 4.8， JCR 1区) 

16.Huixing Zhang#, Jingjing Tan, Hui Zhang, Guanghui An* , Cheng Li*  and Lize Xiong* . Efcacy and Safety of Dexmedetomidine in the Prone Position in Elderly Patients with Pneumonia: A Prospective, Double-Blind, Randomized Controlled Study. Lung. https://doi.org/10.1007/s00408-024-00735-w. Accepted: 25 July 2024. (共同通讯作者，IF: 4.6，JCR 1区) 

 17.Sun X #, Tang J#, Lu J*, Zhang H*, Li C*. Development and validation of a prediction model for mortality in critically ill COVID-19 patients. Front. Cell. Infect. Microbiol., 24 June 2024Sec. Clinical Microbiology. Volume 14 - 2024 | https://doi.org/10.3389/fcimb.2024.1309529. (通讯作者，IF: 4.6，JCR 1区) 

18.Xiaoxiao Sun#, Meixian Zhang#, Hui Zhang, XueJie Fei, Gang Bai*, Cheng Li*. Efficacy and safety of ciprofol forlong-term sedation in patientsreceiving mechanical ventilationin ICUs: a prospective,single-center, double-blind,randomized controlled protocol. Front Pharmacol. 2023 Aug 21;14:1235709. doi: 10.3389/fphar.2023.1235709. eCollection 2023.(通讯作者， IF：4.4，JCR 1区) 

19.Li M#, Liu Z#, Lin F, Wang H, Niu X, Ge X, Fu S, Fang L, Li C*. End-tidal carbon dioxide monitoring improves patient safety during propofol-based sedation for breast lumpectomy: a randomised controlled trial. Eur J Anaesthesiol. 2018 Nov; 35(11):848-855.(通讯作者，IF: 4.14，JCR1区) 

20.Hui Zhang#, QidongLiu#, XiaoruSun, Yaru Xu, Yiling Fang, Silu Cao, Bing Niu*,Cheng Li*.Integrated Bioinformatic and Machine Learning Algorithms analysis highlights related pathways and genes associated with Alzheimer's disease. Current Bioinformatics, 04 February, 2022;17(3):284-295. DOI: 10.2174/1574893617666211220154326（通讯作者，IF:4.0，JCR1区）