一、行政与临床职务
同济大学附属上海市第四人民医院 急诊医学部 主任
同济大学附属上海市第四人民医院 急诊医学二科 主任
二、教学职称
同济大学副教授
三、主要学术任职
中国心胸血管麻醉学会体外生命支持分会 常务委员
中华医学会急诊医学分会 委员
中国医药教育协会 急诊专业委员会 委员
上海市医院协会 急诊管理专业委员会 委员
上海市医院协会 重症医学管理专业委员会 委员
I. Administrative and Clinical Positions
Director, Department of Emergency Medicine, Shanghai Fourth People's Hospital Affiliated to Tongji University
Director, Department of Emergency Medicine II, Shanghai Fourth People’s Hospital Affiliated to Tongji University
II. Teaching Position
Associate Professor, School of Medicine, Tongji University
III. Major Academic Appointments
Standing Committee Member, Extracorporeal Life Support Branch, Chinese Society of Cardiothoracic and Vascular Anesthesiology
Member, Emergency Medicine Branch, Chinese Medical Association
Member, Emergency Professional Committee, China Medicine Education Association
Member, Emergency Management Professional Committee, Shanghai Hospital Association
Member, Critical Care Medicine Management Professional Committee, Shanghai Hospital Association
代表论著：
1. Lili Wang; Fengling Wang; Enqiang Mao; Erzhen Chen; Dayu Chen; Linyu Wang; Yusi Qiu; Xiaolan Bian; Yan Li; Juan He. Pulmonary coinfection by Pneumocystis jirovecii and Aspergillus terreus in an ITP patient after corticosteroid therapy: A case report. VIEW. 2024, 5, 20230051. (通讯作者）
2. Wang, Zhenxia, Yan Li, Xiaowei Yang, LIAN-DONG Zhang, Huiming Shen, Weihong Xu and Congli Yuan. “Protective effects of rapamycin induced autophagy on CLP septic mice.” Comparative immunology, microbiology and infectious diseases 64 (2019): 47-52 .（通讯作者）
3. Hong, Jiehua, Yan Li, Xiuguo Hua, Yajie Bai, Chunyan Wang, Caixia Zhu, Yuming Du, Zhibiao Yang and Congli Yuan. “Lymphatic Circulation Disseminates Bartonella Infection Into Bloodstream.” The Journal of infectious diseases 215 2 (2016): 303-311 .（共一作者）
4. Yan Li, Ming-Zhe Hou, Jian‐guang Wang, Tao Wang, Jian Wan, Binghua Jiao and Zhao-fen Lin. “Changes of lymph metabolites in a rat model of sepsis induced by cecal ligation and puncture.” Journal of Trauma and Acute Care Surgery 73 (2012): 1545–1552.（共一作者）
5. Zhang Xiaoyan,Wang Ruilan,Lu Jian,Jin Wei,Qian Yongbin,Huang Peijie,Tian Rui, Yan Li. Effects of different doses of dexmedetomidine on heart rate and blood pressure in intensive care unit patients.[J] .Exp Ther Med, 2016, 11(1): 360-366.
6. Li Y, Wang JG, Li YP, and Lin ZF. A modified rat model for cannulation and collection of thoracic duct lymph. Lymphology 44: 82-88, 2011.
最新成果：（共同通讯）
Wang H, He P, Wang Z, Tian C, Liu C, Li X, Yan T, Qin Y, Ling S, Ling H, Wu G, Li Y, Wang J, Jin S. Single-cell RNA-seq analysis identifies the atlas of lymph fluid and reveals a sepsis-related T cell subset. Cell Rep. 2025 Apr 22;44(4):115469.
主持的科研项目：
1. 项目编号 81974294：项目名称为“肠 - 淋巴 - 肺通路介导细菌异位致脓毒症急性肺损伤的机制研究”，项目来源为国家自然科学基金委员会（面上项目），经费 55 万元，起止时间为 2020 年 1 月至 2023 年 12 月。该项目聚焦脓毒症发病机制，首次提出 “肠-淋巴 - 肺通路” 在脓毒症急性肺损伤中的关键作用，是团队核心研究方向之一。
2. 项目编号 22JC1403604：项目名称为“基于重症医学数据云的核心数学理论与算法”，项目来源为上海市 2022 年度 “科技创新行动计划” 基础研究领域，经费 30 万元，起止时间为 2022 年 7 月 1 日至 2025 年 6 月 30 日。此项目结合重症医学数据云与数学理论，致力于推动脓毒症诊疗的智能化研究。
3.项目编号 sykyqd01701：项目名称为“肠源性细菌异位致脓毒症急性肺损伤的机制研究”，项目来源为上海市第四人民医院 “科研启动专项经费”，经费 30 万元，起止时间为 2021 年 2 月至 2023 年 1 月。该项目进一步深化肠源性细菌异位与脓毒症的机制研究，与国家级项目形成协同。
4. 项目编号 81372098：项目名称为“Cyclophilin D 在 FFA 诱导内皮细胞坏死性凋亡的机制研究”，项目来源为国家自然科学基金委员会（面上项目），经费 13 万元，起止时间为 2021 年 2 月至 2023 年 2 月。该项目主要围绕内皮细胞凋亡机制展开研究，为脓毒症相关病理机制提供理论支持。
Representative Publications:
1. Lili Wang; Fengling Wang; Enqiang Mao; Erzhen Chen; Dayu Chen; Linyu Wang; Yusi Qiu; Xiaolan Bian; Yan Li; Juan He. Pulmonary coinfection by Pneumocystis jirovecii and Aspergillus terreus in an ITP patient after corticosteroid therapy: A case report. VIEW. 2024, 5, 20230051. (Corresponding Author)
2. Wang, Zhenxia, Yan Li, Xiaowei Yang, LIAN-DONG Zhang, Huiming Shen, Weihong Xu and Congli Yuan. "Protective effects of rapamycin induced autophagy on CLP septic mice." Comparative immunology, microbiology and infectious diseases 64 (2019): 47-52 . (Corresponding Author)
3. Hong, Jiehua, Yan Li, Xiuguo Hua, Yajie Bai, Chunyan Wang, Caixia Zhu, Yuming Du, Zhibiao Yang and Congli Yuan. "Lymphatic Circulation Disseminates Bartonella Infection Into Bloodstream." The Journal of infectious diseases 215 2 (2016): 303-311 . (Co-first author)
4. Li,Yan, Ming-Zhe Hou, Jian‐guang Wang, Tao Wang, Jian Wan, Binghua Jiao and Zhao-fen Lin. "Changes of lymph metabolites in a rat model of sepsis induced by cecal ligation and puncture." Journal of Trauma and Acute Care Surgery 73 (2012): 1545–1552. (Co-first author)
5. Zhang Xiaoyan,Wang Ruilan,Lu Jian,Jin Wei,Qian Yongbin,Huang Peijie,Tian Rui,Li Yan. Effects of different doses of dexmedetomidine on heart rate and blood pressure in intensive care unit patients.[J] .Exp Ther Med, 2016, 11(1): 360-366.
6. Li Y, Wang JG, Li YP, and Lin ZF. A modified rat model for cannulation and collection of thoracic duct lymph. Lymphology 44: 82-88, 2011.
Latest Achievement: (Corresponding Author)
Wang H, He P, Wang Z, Tian C, Liu C, Li X, Yan T, Qin Y, Ling S, Ling H, Wu G, Li Y, Wang J, Jin S. Single-cell RNA-seq analysis identifies the atlas of lymph fluid and reveals a sepsis-related T cell subset. Cell Rep. 2025 Apr 22;44(4):115469.
Research Projects Presided:
1. Project Number 81974294: Project title "Mechanism of acute lung injury in sepsis mediated by the gut-lymph-lung pathway bacterial translocation". Source: National Natural Science Foundation of China (General Program). Funding: 550,000 CNY. Period: Jan 2020 - Dec 2023. This project focuses on the pathogenesis of sepsis, proposing for the first time the key role of the "gut-lymph-lung pathway" in sepsis-induced acute lung injury, and is one of the team's core research directions.
2. Project Number 22JC1403604: Project title "Core mathematical theories and algorithms based on critical care medical data cloud". Source: Shanghai 2022 "Science and Technology Innovation Action Plan" Basic Research Field. Funding: 300,000 CNY. Period: Jul 1, 2022 - Jun 30, 2025. This project combines critical care medical data cloud with mathematical theories, dedicated to promoting intelligent research on sepsis diagnosis and treatment.
3. Project Number sykyqd01701: Project title "Mechanism of acute lung injury in sepsis induced by gut-origin bacterial translocation". Source: Shanghai Fourth People's Hospital "Scientific Research Start-up Fund". Funding: 300,000 CNY. Period: Feb 2021 - Jan 2023. This project further deepens the research on the mechanism of gut-origin bacterial translocation and sepsis, forming synergy with national-level projects.
4. Project Number 81372098: Project title "Mechanism of Cyclophilin D in FFA-induced necrotic apoptosis of endothelial cells". Source: National Natural Science Foundation of China (General Program). Funding: 130,000 CNY. Period: Feb 2021 - Feb 2023. This project primarily focuses on the mechanism of endothelial cell apoptosis, providing theoretical support for sepsis-related pathological mechanisms.
