科研项目:
1. 国家自然科学青年科学基金项目,运动对大鼠损伤远端脊髓内运动神经元的保护作用和机制研究(81000853),2011/01-2013/12,(参加,排名第二)
2. 国家自然科学基金面上项目,骨骼肌-脊髓逆向传导通途对脊髓损伤后神经生长的作用机制(81171851),2011/01-2014/12,(参加,排名第二)
3. 国家自然科学基金面上项目,运动调控BDNF-ERK-CREB -GAD65/67途径减轻脊髓损伤后痉挛的机制研究(81672258),2017/01-2020/12,(参加,排名第二)
4. 江苏省自然基金面上项目,运动训练协同经血干细胞激活 BDNF/CREB/ Bcl-2路促进脊髓损伤修复的机制研究(BK20191182),2019/07-2022/06.(主持,已结题)
5. 国家自然科学基金面上项目,运动协同经血干细胞通过BDNF-PI3K/Akt-CREB通路促进脊髓损伤轴突再生的机制研究(82072536),2021/01-2024/12. (主持,结题)
6. 国家自然科学基金面上项目,3D打印新生鼠脱细胞脊髓/GelMA水凝胶/经血干细胞“两导一芯”支架修复脊髓损伤的研究(82171380 ),2022/01-2025/12. (参加,排名第二)
研究成果:
1. Qinfeng Wu; Yana Cao; Chuanming Dong; Hongxing Wang; Qinghua Wang; Weifeng Tong; Xiangzhe Li; Chunlei Shan; Tong Wang.Neuromuscular interaction is required for neurotrophins-mediated locomotor recovery following treadmill training in rat spinal cord injury.PeerJ,2016,DOI:10.7717/peerj.2025.
2. Qinfeng Wu, Qinghua Wang, Zhangjie Li, Xiangzhe Li, Chuanming Dong. Human menstrual blood-derived stem cells promote functional recovery in a rat spinal cord hemisection model[J]. Cell Death & Disease, 2018, 9(9): 882.
3. 顾倩, 顾琦, 金多沇, 施加加, 吴勤峰(通讯作者). 俯卧撑运动对翼状肩患者肩周肌群表面肌电信号的影响[J]. 中华物理医学与康复杂志, 2018, 40(7):532-535.
4. Xiangzhe Li, Qinfeng Wu, Caizhong Xie, Can Wang, Qinghua Wang, Chuanming Dong, Lu Fang, Jie Ding, Tong Wang. Blocking of BDNF-TrkB signaling inhibits the promotion effect of neurological function recovery after treadmill training in rats with spinal cord injury[J]. Spinal Cord, 2019,57(1):65-74.
5. Xiangzhe Li, Qinghua Wang, Jie Ding, Sheng Wang. Chuanming Dong, Qinfeng Wu (通讯作者). Exercise training modulates glutamic acid decarboxylase-65/67 expression through trkb signaling to ameliorate neuropathic pain in rats with spinal cord injury[J]. Molecular Pain, 2020,16:174480692092451
6. 李向哲,丁洁,方露, 谢财忠, 王庆华, 董传明, 王彤, 吴勤峰(通讯作者). 阻断BDNF-TrkB通路后运动训练对脊髓损伤大鼠痉挛状态及KCC2表达的影响[J]. 中华物理医学与康复杂志,2020,42(7):588-593.
7. Xiangzhe Li, Zhiwei Yang, Sheng Wang, Panpan Xu, Tianqi Wei, Xiaomeng Zhao, Xifeng Li, Yanmei Zhang, Ying Li, Na Mei, Qinfeng Wu(通讯作者). Impact of shoulder subluxation on peripheral nerve conduction and function of hemiplegic upper extremity in stroke patients: A retrospective, matched-pair study. Neurol Res. 2021 Jan 5:1-9. doi: 10.1080/01616412.2020.1870360. Epub ahead of print.
8. Jiahuan Wu, Xiangzhe Li1, Qinghua Wang, Sheng Wang, Wenhua He, Qinfeng Wu(通讯作者)and Chuanming Dong. LncRNA/miRNA/mRNA ceRNA network analysis in spinal cord injury rat with physical exercise therapy[J]. PeerJ. 2022, 10:e13783.
9. Wenhua He, Xuanxuan Zhang, Xiangzhe Li, Dingyue Ju, Tiantian Mao, Yan Lu, Yu Gu, Longju Qi, Qinghua Wang, Qinfeng Wu, Chuanming Dong(共同通讯作者). A decellularized spinal cord extracellular matrix-gel/GelMA hydrogel three-dimensional composite scaffold promotes recovery from spinal cord injury via synergism with human menstrual blood-derived stem cells[J]. J. Mater. Chem. B. 2022, 10(30):5753-5764.
10. Wenhua He, Dingyue Ju, Yu Gu, Yan Lu, Meijuan Ge, Qinfeng Wu(共同通讯作者), Chuanming Dong. Human menstrual blood-derived stem cells combined with a new 3D bioprinted composite scaffold for spinal cord injury treatment[J]. Medical Hypotheses. 2022, https://doi.org/10.1016/j.mehy.2021.110755.
11. Haitao Guan, Qinfeng Wu(共同第一作者), Yuan Zhou, Xing Fan, Kun Zheng, Tong Si, Jinli Zhao. A retrospective study of ultrasound-guided intervention for frozen shoulder in the frozen stage[J]. Front. Surg. 2022 Oct 18;9:998590.
12. Longju Qi, Wenwei Jiang , Wenhua He , Xiangzhe Li , Jiahuan Wu, Shiyuan Chen,Zehua Liao, Shumin Yu1 , Jinyi Liu1 , Yuyu Sun , Qinfeng Wu, Chuanming Dong1 and Qinghua Wang,Transcriptome profile analysis in spinal cord injury rats with transplantation of menstrual blood-derived stem cells[J].Frontiers in Molecular Neuroscience. 2024 DOI 10.3389/fnmol.2024.1335404 .
13. Tianqi Wei, Xiangyang Ge, Lingfeng Lu , Jing L, Panpan Xu and Qinfeng Wu.Efficacy and safety of vagus nerve stimulation on upper extremity motor unction in patients with stroke: A meta-analysis of randomized controlled trials.NeuroRehabilitation .2024 DOI:10.3233/NRE-230106
14. Peng Zhanga , Xiangyu Shenb, Lin Zhangc , Sheng Wanga and Qinfeng Wu Effect of sling exercise combined with Schroth therapy on adolescents with mild idiopathic scoliosis: A twelve-week randomized controlled trial[J]. Journal of Back and Musculoskeletal Rehabilitation.Journal of Back and Musculoskeletal Rehabilitation 37 (2024) 379–388.