博士毕业于中国科学院上海药物研究所，主要从事药物作用新靶点及生物活性新分子研究，揭示抗肿瘤老药可有效调控胚胎干细胞自我更新和体细胞重编程新机制，研究成果在Cell Research杂志上发表。现于同济大学医学院附属妇产科医院从事肿瘤作用机制与靶向抗肿瘤药物的研发，围绕肿瘤发生发病机制和治疗策略，以及肿瘤和肿瘤干细胞的转化应用和机制研究方面的深入研究和新药研发。研究成果已在Science Advances、Cell Death & Disease、Journal of Experimental & Clinical Cancer Research、Cellular & Molecular Biology Letters、Oncogenesis、Cancers等杂志上发表。主持了国家自然科学基金面上项目、青年项目、上海市科委面上项目、同济大学青年优秀人才项目以及干细胞临床研究等相关课题。
Graduated from the Shanghai Institute of Materia Medica, Chinese Academy of Sciences, mainly engaged in the study of new drug targets and new bioactive molecules, revealing the new mechanism by which old anti-tumor drugs can effectively regulate the self-renewal of embryonic stem cells and the reprogramming of somatic cells. The research results were published in the journal Cell Research. Currently, at the School of Medicine, Tongji University, affiliated Obstetrics and Gynecology Hospital, engaged in the research and development of tumor action mechanisms and targeted anti-tumor drugs, focusing on in-depth research and new drug development in the mechanisms and treatment strategies of tumor occurrence and development, as well as the translational application and mechanism research of tumors and tumor stem cells. Research results have been published in journals such as Science Advances, Cell Death & Disease, Journal of Experimental & Clinical Cancer Research, Cellular & Molecular Biology Letters, Oncogenesis, Cancers, etc. Has presided over projects such as the National Natural Science Foundation of China, the Youth Program, the Shanghai Municipal Science and Technology Commission's General Program, the Young Talent Program of Tongji University, and related topics of stem cell clinical research.
近年主持课题:
1.2023.01-2026.12，国家自然科学基金面上项目，HDAC3表观调控cGAS-STING信号通路介导子宫内膜癌干细胞自我更新的机制研究，82273475，主持；
2.2019.01-2021.12，国家自然科学基金青年项目，低氧调控的SOX2去甲基化促进子宫内膜癌干细胞自我更新的分子机制研究，81802960，主持；
3.2022.04-2025.03，上海市自然科学基金面上项目，子宫内膜癌POLE突变通过cGAS通路提高PD-1/ PD-L1抑制剂敏感度的机制研究，22ZR1449100，主持；
4.2020.06-2023.06，院级优秀人才项目，细胞程式死亡配体PD-L1调控子宫内膜癌干细胞自我更新的分子机制研究，2020RC09，主持；
5.2018.10-2019.9，同济大学干细胞临床研究课题，人子宫内膜干细胞在子宫内膜损伤修复中的作用和机制研究，2017A04，主持；
6.2018.01-2019.12，同济大学青年优秀人才项目，肿瘤微环境中HIFs信号调控人子宫内膜癌干细胞休眠与激活的分子机制研究，22120180035，主持；
7.2017.09-2018.03，同济大学附属妇产科医院院级课题，VEGF/VEGFR信号通路调控子宫内膜干细胞自我更新和内膜细胞再生及其在子宫内膜癌中的作用机制研究，2018A02，主持；
8.2016/01-2017/12，中国博士后科学基金面上项目一等资助，Aβ与Aβ受体的生化与结构鉴定，Y512031078，主持；
Principal Investigator of Research Projects
1.Research on the Mechanism of HDAC3 Epigenetic Regulation of cGAS-STING Signaling Pathway in the Self-Renewal of Endometrial Cancer Stem Cells, National Natural Science Foundation of China, 2023.01-2026.12, Grant No. 82273475, Principal Investigator (PI).
2.Molecular Mechanism Study on Hypoxia-Regulated Demethylation of SOX2 Promoting Self-Renewal of Endometrial Cancer Stem Cells, National Natural Science Foundation of China Youth Program, 2019.01-2021.12, Grant No. 81802960, PI.
3.Mechanism Study on Endometrial Cancer POLE Mutation Enhancing Sensitivity to PD-1/PD-L1 Inhibitors through the cGAS Pathway, Shanghai Municipal Natural Science Foundation, 2022.04-2025.03, Grant No. 22ZR1449100, PI.
4.Molecular Mechanism Study on the Regulation of Endometrial Cancer Stem Cell Self-Renewal by the Cell Death Ligand PD-L1, Outstanding Talent Program of Tongji University, 2020.06-2023.06, Grant No. 2020RC09, PI.
5.Role and Mechanism of Human Endometrial Stem Cells in the Repair of Endometrial Injury, Stem Cell Clinical Research Project of Tongji University, 2018.10-2019.9, Grant No. 2017A04, PI.
6.Molecular Mechanism Study on HIFs Signaling Regulating Dormancy and Activation of Human Endometrial Cancer Stem Cells in the Tumor Microenvironment, Young Talent Program of Tongji University, 2018.01-2019.12, Grant No. 22120180035, PI.
7.Study on the Role and Mechanism of VEGF/VEGFR Signaling Pathway in the Self-Renewal of Endometrial Stem Cells and Regeneration of Endometrial Cells and Its Role in Endometrial Cancer, Institutional Project, 2017.09-2018.03, Grant No. 2018A02, PI.
8.Biochemical and Structural Identification of Aβ and Aβ Receptors, China Postdoctoral Science Foundation, 2016/01-2017/12, First-Class Funding, Grant No. Y512031078, PI.
