The laboratory focuses on:
1. The role of signal regulation, transcriptional regulation, apparent regulation and metabolic regulation in the development and evolution of human nerve
2. Functional subtype specific neuron acquisition and nerve regeneration
3. Research on the construction and treatment strategy of neural disease model
4. Human pluripotent stem cell gene editing
Education Background
1998 Undergraduate degree of clinical medicine, Nantong University
2005 Doctorate of pharmacology, Fudan University
2006-2010 2 years of postdoctoral life and 3 years of young scientists, University of Wisconsin-Madison, USA
Positions Held
2011 Special invited professor and doctoral tutor, Tongji University
Present the vice dean of graduate school, Tongji University
Secretary of the Commission for Discipline, School of Medicine
Chief PI, Shanghai Tongji Hospital
The leader of Neurogeneration Key Laboratory of Shanghai Universities
Chief scientist, the National major scientific research program
Excellent academic pace-setter, Shanghai
1. The mechanism of human neurodevelopment
Focusing on the development of human brain, the origin of nervous system, the regional characteristics of nervous system, and how functional neurons and glial cells are gradually constructed, and eventually form the human brain. Our laboratory have established a perfect platform for neural differentiation, which can simulate the whole development process of the nervous system, including neuroectodermal generation, localization and neural or glial regeneration.
2. Construction and application of neural system disease model
An important application of human pluripotent stem cells is to simulate the production of diseases in vitro, which can be used in the construction of cell models and drug screening. Our laboratory used pluripotent stem cells to build a glioblastoma (GBM) model to simulate the generation process of GBM, and to simulate the specific neurogenetic diseases, such as spinal muscular atrophy (SMA), to study its pathogenesis and treatment.
3. Cell replacement therapy
Neurodegenerative diseases, such as Parkinson, epilepsy and Alzheimer's disease, are severe diseases of the nervous system. The treatment of these diseases is mainly focused on nursing and rehabilitation, and the curative effect is not remarkable. Remolding the damaged neural circuits is the ultimate way to completely alleviate these diseases based on cell replacement therapy. Human pluripotent stem cells can differentiate into various kinds of neural precursor cells (NPC). In the mouse model, NPC transplantation has been proved to be able to correct the phenotype of Parkinson, epilepsy, and Alzheimer's disease. Therefore, cell replacement therapy which based on NPC is becoming an important way to completely alleviate and cure these diseases.
Awards: -
