Tongji University School of Medicine


  • NAME:Zhang, Xiaoqing
  • OFFICE LOCATION: Room 702, 1239 Siping Road, Tongji University School of Medicine, Shanghai
  • KEY WORDS: Neural Differentiation of Stem Cells
  • CONTACT INFO: Tel: 86-21-65985003 Email:

The laboratory focuses on:

1. The role of signal regulation, transcriptional regulation, apparent regulation and metabolic regulation in the development and evolution of human nerve

2. Functional subtype specific neuron acquisition and nerve regeneration

3. Research on the construction and treatment strategy of neural disease model

4. Human pluripotent stem cell gene editing

Education Background

1998 Undergraduate degree of clinical medicine, Nantong University

2005 Doctorate of pharmacology, Fudan University

2006-2010 2 years of postdoctoral life and 3 years of young scientists, University of Wisconsin-Madison, USA

Positions Held

2011 Special invited professor and doctoral tutor, Tongji University

Present the vice dean of graduate school, Tongji University

Secretary of the Commission for Discipline, School of Medicine

Chief PI, Shanghai Tongji Hospital

The leader of Neurogeneration Key Laboratory of Shanghai Universities

Chief scientist, the National major scientific research program

Excellent academic pace-setter, Shanghai

1. The mechanism of human neurodevelopment

Focusing on the development of human brain, the origin of nervous system, the regional characteristics of nervous system, and how functional neurons and glial cells are gradually constructed, and eventually form the human brain. Our laboratory have established a perfect platform for neural differentiation, which can simulate the whole development process of the nervous system, including neuroectodermal generation, localization and neural or glial regeneration.

2. Construction and application of neural system disease model

An important application of human pluripotent stem cells is to simulate the production of diseases in vitro, which can be used in the construction of cell models and drug screening. Our laboratory used pluripotent stem cells to build a glioblastoma (GBM) model to simulate the generation process of GBM, and to simulate the specific neurogenetic diseases, such as spinal muscular atrophy (SMA), to study its pathogenesis and treatment.

3. Cell replacement therapy

Neurodegenerative diseases, such as Parkinson, epilepsy and Alzheimer's disease, are severe diseases of the nervous system. The treatment of these diseases is mainly focused on nursing and rehabilitation, and the curative effect is not remarkable. Remolding the damaged neural circuits is the ultimate way to completely alleviate these diseases based on cell replacement therapy. Human pluripotent stem cells can differentiate into various kinds of neural precursor cells (NPC). In the mouse model, NPC transplantation has been proved to be able to correct the phenotype of Parkinson, epilepsy, and Alzheimer's disease. Therefore, cell replacement therapy which based on NPC is becoming an important way to completely alleviate and cure these diseases.

Awards: -

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