Zheng, Jialin-医学院

NAME:Zheng, Jialin
OFFICE LOCATION: Room 305, 1rst building, 301 Yanchangzhong Road, Jingan, District, Shanghai
KEY WORDS: Brain Disorders and Stem Cell Research
CONTACT INFO: Tel: 201-66307449 Email: njbgxb@163.com

INTRODUCTION
RESEACH AREA
PUBLICATIONS

The laboratory relies on the research platform of Medical College of Tongji University and the Tenth People's Hospital affiliated Tongji University, carrying out immunization, exosomes and vesicles as the main object of neuroimmunology research which based on neural stem cells and neuroimmunological study , as well as basic research on the survival, differentiation, migration and functionalization of neural stem cells in neuroinflammatory environment, and explore the influence of various cytokines and stem cells on the pathogenesis and neural repair of human main nervous system diseases. At the same time, using stem cells as a tool and means to develop cell therapy / immunotherapy and research on transformation medicine of neuropsychotropic drug screening

Education Background

1. 2006.9-2008.12 Doctorate of Neurology, Shanghai Jiao Tong University School of Medicine

2. 1991.9-1992.10 Doctorate of Neuropharmacology, Shanghai Jiao Tong University School of Medicine

3. 1987.9-1990.7 Master’s degree of Neuropharmacology, Nanjing Medical University

4. 1982.9-1987.7 Bachelor of Medicine, Xuzhou Medical University

Positions Held

Present: the Dean of Tongji University School of Medicine

Once: the Director of the Department of medicine and Life Sciences, Tongji University;

Vice Chancellor of the University of Nebraska Medical Center Research Associate, and vice president of graduate school;

Professor of pharmacology, neuroscience, family medicine and rehabilitation therapy at the University of Nebraska Medical Center (UNMC)

1. Optimal induction of neural progenitor cells and identification of their function.

2. Study on the mechanism of regulating the differentiation and development of neural progenitor cells

3. The role of extracellular vesicles in the process of neurotransmission and the mechanism of release

4. The mechanism and approach of neural stem cells for the repair of Alzheimer's disease (AD) and Parkinson's disease (PD) nerve injury

5. The study of the formation and function of the neural circuits

Awards: -

1. Min Zhang^#, Lisha Qiu^#, Yanyan Zhang,Dongsheng Xu,Jialin C. Zheng*,Li Jiang*. (2017)CXCL12 enhances angiogenesis through CXCR7 activation in human umbilical vein endothelial cells.Sci Rep. Aug 15;7(1):8289.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557870/

2. Yuju Li, Justin Peer, Runze Zhao, Yinghua Xu, Beiqing Wu, Yi Wang, Changhai Tian, Yunlong Huang*, and Jialin Zheng*. （2017）Serial deletion reveals structural basis and stability for the core enzyme activity of human glutaminase 1 isoforms: relevance to excitotoxic neurodegeneration. Transl Neurodegener. Apr 20;6:10.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399437/

3. Yi Wang^#, Yuju Li^#, Runze Zhao^#, Beiqing Wu, Blaise Lahona, Zenghan Tong, Justin Peer, Jianhui Liu, Huangui Xiong, Yunlong Huang*, and Jialin Zheng*. （2017）Glutaminase C overexpression in the brain induces learning deficits, synaptic dysfunctions, and neuroinflammation in mice. Brain, Behavior, and Immunity. Jun 14.

http://www.sciencedirect.com/science/article/pii/S0889159117301964?via%3Dihub

4. Peipei Xu, Yingchun Wang, Zhao Qin, Lisha Qiu, Ming Zhang, Yunlong Huang*, and Zheng J*.（2017） Combined medication of antiretroviral drugs tenofovir disoproxil fumarate, emtricitabine, and raltegravir reduces neural progenitor cell proliferation in vivo and in vitro. Journal of Neuroimmune Pharmacology. Jul 22.

https://link.springer.com/article/10.1007%2Fs11481-017-9755-4

5. Kaizhe Wang^#, Ling Ye^#, Hongfang Lu, Huili Chen, Yanyan Zhang, Yunlong Huang*and Jialin C. Zheng*.（2017）TNF-α promotes extracellular vesicle release in mouse astrocytes through glutaminase. Journal of Neuroinflammation, 14:87

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399318/

6. Y. Wang, P. Xu, L. Qiu, M. Zhang, Y. Huang*, and J.C. Zheng*.(2016) CXCR7 Participates in CXCL12-mediated Cell Cycle and Proliferation Regulation in Mouse Neural Progenitor Cells. Current Molecular Medicine. 16(8):738-746.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5345320/

7. Smith, D.K., He, M., Zhang C.L., and Zheng, J. (2016). The therapeutic potential of cell identity reprogramming for the treatment of aging-related neurodegenerative disorders. Prog Neurobiol. Feb 1.

http://www.sciencedirect.com/science/article/pii/S0301008215300678?via%3Dihub

8. Lai, S., Zhang, M., Xu, D., Zhang, Y., Qiu, L., Tian, C.* and Zheng, J*. (2015). Direct Reprogramming of Induced Neural Progenitors: A New Promising Strategy for Alzheimer’s diseases treatment. Translational Neurodegeneration .Apr 18; 4:7.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422611/

9. Tian, C*., Li, Y., Huang, Y., Wang, Y., Chen, D., Liu, J., Deng, X., Sun, L., Anderson, K., Qi, X., Li, Y., R. Lee Mosley, R.L., Chen, X., Huang, J. and Zheng, J*. (2015). Selective Generation of Dopaminergic Precursors from Mouse Fibroblasts by Direct Lineage Conversion. Scientific Reports.Jul 30;5:12622.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4519786/

10. Liu, F., Huang, Y., Zhang, F., Chen, Q., Wu, B., Wei, R., Zheng, J.* and Ding, W*. (2015). Macrophages treated with particulate matter PM2.5 induce selective neurotoxicity through glutaminase-mediated glutamate generation. J Neurochem. Jul;134(2):315-26 .

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709176/

11. Zhang, M., Song, A., Lai, S., Qiu, L., Huang, Y., Chen, Q., Zhu, B., Xu, D*., Zheng, J.*(2015).Applications of stripe assay in the study of CXCL12-mediated neural progenitor cell migration and polarization. Biomaterials. Dec;72:163-71.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830438/

12. Wu, B., Huang, Y*., Braun, A.L., Tong, Z., Zhao, R., Li, Y., Liu, F. and Zheng, J.C*. (2015). Glutaminase-containing microvesicles from HIV-1-infected macrophages and immune-activated microglia induce neurotoxicity. Molecular Neurodegeneration. Nov 6;10(1):61.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635976/

13. Chen, Q., Zhang, M., Li, Y., Xu, D*, Wang Y., Song A., Zhu B., Huang, Y.* and Zheng, J*. (2015). CXCR7 Mediates Neural Progenitor Cells Migration to CXCL12 Independent of CXCR4. Stem Cells.134(2):315-26.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4867224/

14. Dongsheng Xu*, , Yanyan Zhang, Lingjun Zhao, Mingxia Cao,Amy Lingel, Luwen Zhang. *.（2015）. Interferon regulatory factor 7 is involved in the growth of Epstein–Barr virus-transformed human B lymphocytes. Virus Res. Jan 2;195:112-8.

https://linkinghub.elsevier.com/retrieve/pii/S0168-1702(14)00379-7

15. Wang, Y., Huang, Y., Zhao, L. and Zheng, J. (2014). Glutaminase 1 Is Essential for the Differentiation, Proliferation, and Survival of Human Neural Progenitor Cells. Stem Cells and Development . Nov15;23(22):2782-90.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216480/

16. Al-Harthi, L., Buch, S., Geiger, JD, Gendelman, HE, He, JJ, Jordan-Sciutto, KL, Kolson, DL, Rappaport, J, Roy, S, Zheng, J, Fox, HS. (2014). Cellular Interactions and Signaling in neuroAIDS: Emerging Issues Colloquium. J Neuroimmune Pharmacol. Jun 9(3): 269-76.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104811/

17. Dalian Zhong*,and Paul Blount.Electrostatics at the membrane define MscL channel mechanosensitivity and kinetics.FASEB J. 2014 Dec;28(12):5234-41.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232281/

18. Tian, C., Liu, Q., Ma, K., Wang, Y., Chen, Q., Ambroz, R., Klinkebiel, D., Li, Y.,Huang, Y., Ding, J., Wu, J. and Zheng, J. (2013). Characterization of Induced Neural Progenitors from Skin Fibroblasts by a Novel Combination of Defined Factors. Scientific Reports. 3:1345.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581826/

19. Tian, C. and Zheng, J. (2013). Neural Progenitors by Direct Reprogramming: Strategies for the Treatment of Parkinson’s and Alzheimer's Diseases. Science (Supplement Issue)

20. Ye, L., Huang, Y., Zhao, L., Li, Y., Sun, L., Zhou, Y., Qian, G. and Zheng, J. (2013). IL-1β and TNF-α induce neurotoxicity through glutamate production: a potential role for neuronal glutaminase. J. Neurochem. Jun;125(6):897-908.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747774/

21. Zheng, J., and Tong, Z. (2013). Exciting progresses in stem cell and neural stem cell research. Curr Mol Med. Nov;13(9):1409-11.

http://www.eurekaselect.com/114626/article

22. Chen, E., Xu, D., Lan, X., Jia, B., Sun, L., Zheng, J. and Peng, H. (2013). A Novel Role of the STAT3 Pathway in Brain Inflammation-induced Human Neural Progenitor Cell Differentiation. Current Molecular Medicine. Nov;13(9):1474-84.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4157724/

23. Ye, L., Zhao, X., Lu, J., Qian, G., Zheng, J. and Ge, S. (2013). Knockdown of TIGAR by RNA interference induces apoptosis and autophagy in HepG2 hepatocellular carcinoma cells. Biochem and Biophys Res Commun . Jul 26;437(2):300-6.

http://www.sciencedirect.com/science/article/pii/S0006291X1301070X?via%3Dihub

24. Wang, Y., Tian, C and Zheng, J. (2013). FoxO3a contributes to the reprogramming process and the differentiation of induced pluripotent stem cells. Stem Cells Dev. Nov 15;22(22):2954-63.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3822390/

25. Zhao, L., Huang, Y. and Zheng, J. (2013). STAT1 regulates human glutaminase 1 promoter activity through multiple binding sites in HIV-1 infected macrophages. PLOS ONE .Sep 24;8(9):e76581 .

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782442/

26. Xu D, Staedman A, Zhang L.( 2013).CD20 antibody primes B lymphocytes for type I interferon production.PLoS One. Jun 18;8(6):e67900.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3707517/

27. Zhao, L., Huang, Y., Tian, C., Taylor, L., Curthoys, N., Wang, Y., Vernon, H. and Zheng, J. (2012). Interferon-α regulates glutaminase 1 promoter through STAT1 phosphorylation: Relevance to HIV-1 associated neurocognitive disorders. PLOS ONE. 7(3):e32995.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3316554/

28. Tian, C., Ambroz, R., Sun, L., Wang, Y., Ma, K., Chen, Q., Zhu, B. and Zheng, J. (2012). Direct conversion of dermal fibroblasts into neural progenitor cells by a novel cocktail of defined factors. Current Molecular Medicine. Feb;12(2):126-37.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3434966/

29. Huang, X., Tian, C., Liu, M., Wang, Y., Tolmachev, A., Sharma, S., Fang, Y., Fu, K., Zheng, J., and Ding, S. (2012). Quantitative Proteomic Analysis of Mouse Embryonic Fibroblasts and Induced Pluripotent Stem Cells Using 16O /18O labeling. J Proteome Res. Apr 6;11(4):2091-102.

http://pubs.acs.org/doi/abs/10.1021/pr300155r

30. Tian, C., Sun, L., Jia, B., Ma, K., Curthoys N., and Zheng, J. (2012). Mitochondrial glutaminase release contributes to glutamate-mediated neurotoxicity during human immunodeficiency virus -1 infection. J. Neuroimmune Pharmacol. Sep;7(3):619-28.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3924960/

31. Wu, Y., Chen, Q., Peng, H., Dou, H., Zhou, Y., Huang, Y., and Zheng, J. (2012). Directed migration of human nueral progenitor cells to interleukin-1b is promoted by chemokines stromal cell-derived factor-1 and monocyte chemotactic factor-1 in mouse brains. Translational Neurodegeneration .Jul 31;1(1):15.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3522560/

32. Zhu, B, Xu, D., Deng, X., Chen, Q., Huang, Y., Peng, P., Li, Y., Jia, B., Wallace B. Thoreson, W.B., Ding, W., Ding, J., Zhao, L., Wang, Y., Wavrin, K.L., Duan, S., Zheng, J. (2012). CXCL12 Enhances Human Neural Progenitor Cells Survival through a CXCR7- and CXCR4-mediated Endocytotic Signaling Pathway. Stem Cells. Nov;30(11):2571-83.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969741/

33. Peng H, Wu Y, Duan Z, Ciborowski P, Zheng JC. (2012). Proteolytic processing of SDF-1α by matrix metalloproteinase-2 impairs CXCR4 signaling and reduces neural progenitor cell migration. Protein Cell. Nov;3(11):875-82.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973535/

34. Lan, X., Chen, Q., Wang, Y., Jia, B., Sun, L., Zheng, J. and Peng, H. (2012). TNF-α Affects Human Cortical Neural Progenitor Cell Differentiation through the Autocrine Secretion of Leukemia Inhibitory Factor. PLoS One. 7(12):e50783.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3517586/

35. X. Lan, T. Kiyota, R. Hanamsagar, Y. Huang, S. Andrews, H. Peng, J. Zheng, S. Swindells, G. Carlson, T. Ikeyu. (2012) The effect of HIV protease inhibitors on amyloid-b peptide degradation and synthesis in human cells and Alzheimer’s disease animal model. J. Neuroimmune Pharmacol. Jun;7(2):412-23.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3223330/

36. Tian, C and Zheng, J. (2011) .Reprogrammed Astrocytes as a Potential Therapy for Neurodegenerative Disorders. Science. (Supplement Issue, S. Sanders Ed., Science/AAAS, Washington, DC, 2011), pp. [53-54]. (NIHMS: 347017)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4217696/

37. Huang, Y., Zhao, L., Jia, B., Li, Y., Curthoys, N., Zheng, J. (2011) Glutaminase dysregulation in HIV-1-infected human microglia mediates neurotoxicity: relevant to HIV-1 associated neurocognitive disorders. J. Neurosci. Oct 19;31(42):15195-204.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407550/

38. Huang, X., Liu, M., Nold, M., Tian, C., Fu, K., Zheng, J., Geromanos, S., Ding, S. (2011). Software for Quantitative Proteomic Analysis using Stable Isotope Labeling and Data Independent Acquisition. Anal. Chem. Sep 15;83(18):6971-9.

http://pubs.acs.org/doi/abs/10.1021/ac201555m

39. Hou, J, Dong, J., Sun, L., Geng, L., Wang, J., Zheng, J., Li, Y., Bridge, J., Hinrichs, S., and Ding, S. （2011） Inhibition of phosphorylated c-Met in rhabdomyosarcoma cell lines by a small molecule inhibitor SU11274. J. Transl. Med. May 16;9:64 .

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3212957/

40. Peng, H., Sun, L., Jia, B., Lan, X., Zhu, B., Wu, Y., and Zheng, J. (2011). HIV-1-Infected and immune-activated macrophages induce astrocytic differentiation of human cortical neural progenitor cells through the STAT3 pathway. PLOS ONE.6(5):e19439.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3103496/

41. Lan, X., Xu, J., Kiyota, T., Peng, H., Zheng, J., Ikezu, T. (2011). HIV-1 reduces Aβ-degrading enzymatic activities in primary human mononuclear phagocytes. J. Immunology. 186(12):69250-32.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3110566/

42. Tian, C., Wang, Y., Sun, L., Ma, K. and Zheng, J. (2011). Reprogrammed Mouse Astrocytes Retain a “Memory” of Tissue Origin and Possess More Tendencies for Neuronal Differentiation than Reprogrammed MEFs. Protein & Cell. Feb;2(2):128-40.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407551/

43. Cui, M., Huang, Y., Tian, C., Zhao, Y. and Zheng, J. (2011). FOXO3a inhibits TNF-a and IL-1b induced astrocyte proliferation: implication for reactive astrogliosis. GLIA. Apr;59(4):641-54.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747776/

44. Letendre , S.L., Zheng, J., Kaul, M., Yiannoutsos4, C.T., Ellis, R., Taylor, M., Marquie-Beck, J., Navia, B. and for the HIV Neuroimaging Consortium (2011). Chemokines in cerebrospinal fluid correlate with cerebral metabolite patterns in HIV-infected individuals. J. NeuroVirology 17(1):63-9.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3032187/

45. Constantino, A., Huang, Y., Zhang, H., Wood, C., and Zheng, J. (2011). HIV-1 Clade B and C Isolates Exhibit Differential Replication: Relevance to Macrophage-Mediated Neurotoxicity. Neurotox. Res. 20(3):277-88.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407549/