Focusing on Molecular and Cellular Cardiology, including:
1. Molecular biological mechanisms of cardiac hypertrophy and heart failure
2. Molecular mechanisms of cardiomyocyte differentiation.
Education Background
1996/11 - 2000/5, University of Tokyo, Japan, Department of cardiovascular medicine, received a doctor's degree
1984/9 - 1990/7, Second Military Medical University, Shanghai, Department of clinical medicine, received a bachelor's degree.
Positions Held
2009/12- today, Tongji University, affiliated Orient Hospital, Professor
2003/2-2009/12, Chiba University, medical school, assistantship
2001/7-2002/12, Harvard University, children's Hospital Cardiovascular Research Center, postdoctoral
1. Wo D#, Peng J#, Ren DN#, Qiu L#, Chen J, Zhu Y, Yan Y, Yan H, Wu J, Ma E, Zhong TP, Chen Y, Liu Z, Liu S, Ao L, Liu Z, Jiang C, Peng J, Zou Y*, Qian Q*, Zhu W*. Opposing Roles of Wnt Inhibitors IGFBP-4 and Dkk1 in Cardiac Ischemia by Differential Targeting of LRP5/6 and β-catenin. Circulation 2016; 134:1991-2007
https://www.ncbi.nlm.nih.gov/pubmed/27803037
2. He Q, Yan H, Wo D, Liu J, Liu P, Zhang J, Li L, Zhou B, Ge J, Li H, Liu S*, Zhu W*. Wnt3a suppresses Wnt/β-catenin signaling and cancer cell proliferation following serum deprivation. Exp Cell Res, 2016; 341:32-41
https://www.ncbi.nlm.nih.gov/pubmed/26643293
3. Ren DN#, Chen J#, Li Z#, Yan H, Yin Y, Wo D, Zhang J, Ao L, Chen B, Ito TK, Chen Y, Liu Z, Li Y, Yang J, Lu X, Peng Y, Pan L, Zhao Y, Liu S, Zhu W. LRP5/6 directly bind to Frizzled and prevent Frizzled-regulated tumour metastasis. Nat Commun, 2015; 6:6906
https://www.ncbi.nlm.nih.gov/pubmed/25902418
4. Chen J#, Yan H#, Ren DN#, Yin Y#, Li Z, He Q, Wo D, Ho MS, Chen Y, Liu Z, Yang J, Liu S, Zhu W. LRP6 dimerization through its LDLR domain is required for robust canonical Wnt pathwayactivation. Cell Signal, 2014; 26:1068-1074
https://www.ncbi.nlm.nih.gov/pubmed/24412751
5. Zhu W, Shiojima I, Ito Y, Li Z, Ikeda H, Yoshida M, Naito AT, Nishi J, Ueno H, Umezawa A, Minamino T, Nagai T, Kikuchi A, Asashima M, Komuro I. IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis. Nature 2008;454:345-9
https://www.ncbi.nlm.nih.gov/pubmed/18528331
6. Harada M, Qin Y, Takano H, Minamino T, Zou Y, Toko H, Ohtsuka M, Matsuura K, Sano M, Nishi J, Iwanaga K, Akazawa H, Kunieda T, Zhu W, Hasegawa H, Kunisada K, Nagai T, Nakaya H, Yamauchi-Takihara K, Komuro I. G-CSF prevents cardiac remodeling after myocardial infarction by activating the Jak-Stat pathway in cardiomyocytes. Nat Med 2005;11:305-11
https://www.ncbi.nlm.nih.gov/pubmed/15723072
7. Zhu W, Shiojima I, Hiroi Y, Zou Y, Akazawa H, Mizukami M, Toko H, Yazaki Y, Nagai R, Komuro I. Functional analyses of three Csx/Nkx-2.5 mutations that cause human congenital heart disease. J Biol Chem 2000;275(45):35291-6
https://www.ncbi.nlm.nih.gov/pubmed/10948187
8. Zhu W, Zou Y, Shiojima I, Kudoh S, Aikawa R, Hayashi D, Mizukami M, Toko H, Shibasaki F, Yazaki Y, Nagai R, Komuro I. Ca2+/calmodulin-dependent kinase II and calcineurin play critical roles in endothelin-1-induced cardiomyocyte hypertrophy. J Biol Chem 2000;275:15239-45
https://www.ncbi.nlm.nih.gov/pubmed/10809760
9. Zhu W, Zou Y, Aikawa R, Harada K, Kudoh S, Uozumi H, Hayashi D, Gu Y, Yamazaki T, Nagai R, Yazaki Y, Komuro I. MAPK superfamily plays an important role in daunomycin-induced apoptosis of cardiac myocytes. Circulation 1999;100(20):2100-7
https://www.ncbi.nlm.nih.gov/pubmed/10562267
10. Zou Y#, Zhu W#, Sakamoto M, Qin Y, Akazawa H, Toko H, Mizukami M, Takeda N, Minamino T, Takano H, Nagai T, Nakai A, Komuro I. Heat shock transcription factor 1 protects cardiomyocytes from ischemia/reperfusion injury. Circulation 2003;108:3024-30
https://www.ncbi.nlm.nih.gov/pubmed/14623809
11. Monzen K#, Zhu W#, Kasai H, Hiroi Y, Hosoda T, Akazawa H, Zou Y, Hayashi D, Yamazaki T, Nagai R, Komuro I. Dual effects of the homeobox transcription factor Csx/Nkx2-5 on cardiomyocytes. Biochemical and Biophysical Research Communications 2002;298:493-500
https://www.ncbi.nlm.nih.gov/pubmed/12408979
12. Toko H#, Zhu W#, Takimoto E, Shiojima I, Hiroi Y, Zou Y, Oka T, Akazawa H, Mizukami M, Sakamoto M, Terasaki F, Kitaura Y, Takano H, Nagai T, Nagai R, Komuro I. Csx/Nkx2-5 is required for homeostasis and survival of cardiac myocytes in the adult heart. Journal of Biological Chemistry 2002;277:24735-43
https://www.ncbi.nlm.nih.gov/pubmed/11889119
13. Zou Y, Yao A, Zhu W, Kudoh S, Hiroi Y, Shimoyama M, Uozumi H, Kohmoto O, Takahashi T, Shibasaki F, Nagai R, Yazaki Y, Komuro I. Isoproterenol activates extracellular signal-regulated protein kinases in cardiomyocytes through calcineurin. Circulation 2001;104:102-109
https://www.ncbi.nlm.nih.gov/pubmed/11435346
