Focusing on Organ Regeneration, including:
1. The mechanism of the lung, kidney, uterus, liver, intestine, bladder and other visceral organ regeneration
2. The production of tissue engineering artificial organs
3. The gene editing and special organs’ construction based on CRISPR
4. The cross species chimera and ultra ability acquisition
5. Study on the high-throughput sequencing and complex systems biology
6. The mechanisms of malignant transformation of adult stem cells and benign transformation of tumor
7. The autologous stem cell transplantation and organ regeneration in clinical research
Education Background
2002-2006 Bachelor, School of Life Science, Sichuan University
2006-2011 Doctor, School of Life Science, Tsinghua University
Positions Held
1. The chief scientist of the National Key R&D Plan
2. The director of the stem cell Institute, Jiangnan-Zhejiang Province
3. Expert of the Recruitment Program of Global Experts
4. Young Scholar of Changjiang Scholar Award, the Ministry of education
5. The project leader of the first batch of stem cell clinical studies, the National Health Planning Commission and Drug Administration Bureau
6. The director of organ regeneration laboratory, clinical transformation center of Shanghai Pulmonary Hospital
7. Special invited expert, Shanghai East Hospital
8. Visiting Professor, Army Medical University
9. Visiting Professor, the first hospital affiliated Guangzhou Medical University
1. The mechanism of the lung, kidney, uterus, liver, intestine, bladder and other visceral organ regeneration
2. The production of tissue engineering artificial organs
3. The gene editing and special organs’ construction based on CRISPR
4. The cross species chimera and ultra ability acquisition
5. Study on the high-throughput sequencing and complex systems biology
6. The mechanisms of malignant transformation of adult stem cells and benign transformation of tumor
7. The autologous stem cell transplantation and organ regeneration in clinical research
Awards: The only winner of the GIS prize for scientific and technological achievements of the Singapore Science and Technology Bureau in 2014
1. Ma Q, Wang Y, Zuo W#. (2017). Notch-mediated Sox9 activation contributes to kidney repair after partial nephrectomy. Life Sciences (in press)
2. Ma Q, Ma Y, Zhang T, Zuo W#. (2017). Organ size control mechanism in animals. Science Bulletin 62（7），626-630.
3. Zhang T, Li S, Zuo W#. (2015). Landscape of protein interactome. Protein & Cell 6(8), 610-614.
4. Zuo W, Zhang T, Wu DZ, Guan SP, Liew AA, Lim T, Yamamoto Y, Wang X, Lim SJ,Vincent M, Lessard M, Crum CP, Xian W, McKeon F. (2015). p63+/Krt5+ distal airway stem cells are essential for lung regeneration. Nature 517,616-620. (“F1000”recommended; Highlighted and commented by Nature, Nature Biotechnology, Transplantation, European Journal of Respiratory )
5. Zuo W, Chen YG. (2013). TGF-β signaling in hematopoietic stem cells and leukemia. Cancer Hallmarks1, 91-97.
6. Zuo W, Huang F, Chiang J, Li M, Du J, Ding Y, Zhang T, Lee HW, Jeong LS, Chen YL, Deng HT, Feng XH, Luo SW, Gao CJ, Chen YG. (2013). c-Cbl-mediated neddylation antagonizes ubiquitination and degradation of TGF-β type II receptor. Mol Cell 49 (3), 499-510 (“F1000”recommended )
7. Zhou H, Zuo W, Chen YG.(2012). Endocytosis. Molecular Cell Biology (book title) (invited book chapter), Tsinghua University Press.(in Chinese)
8. Gao C. Cao WP, Bao L,Zuo W, Xie GM, Cai TT, Fu W, Zhang J, Wu W, Zhang X, Chen YG. (2010). Autophagy negatively regulates Wnt signaling by promoting Dishevelled degradation. Nat Cell Biol 12(8), 781-790.
9. Zhang W, Yuan J, Yang Y, Xu L, Wang Q, Zuo W, Fang X, Chen YG. (2010) Monomeric type I and type III transforming growth factor-β receptors and their dimerization. Cell Research 20(11), 1216-1223.
10. Zhang W, Jiang Y, Wang Q, Ma X, Xiao Z, Zuo W, Fang X, Chen YG. (2009) Single-molecule imaging reveals transforming growth factor-beta-induced type II receptor dimerization. Proc Natl Acad Sci USA 106(37), 15679-15683.
11. Zuo W, Zhao XG, Chen YG (2009). SARS-CoV and lung fibrosis. Molecular Biology of the SARS-Coronavirus (book title) (invited book chapter), Springer Press.
12. Zuo W, Chen YG (2009). Specific activation of mitogen-activated protein kinase by transforming growth factor-beta receptors in lipid rafts is required for epithelial cell plasticity.Mol Biol Cell 20(3), 1020-1029.
