Tongji University School of Medicine

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  • NAME:Cheng, Yu
  • OFFICE LOCATION: 67 Chifeng Rd. Shanghai, 200092, P.R. China
  • KEY WORDS: Multifunctional nanomaterials for biomedical applications.
  • CONTACT INFO: Tel: 021-65983706-215 Email: yucheng@tongji.edu.cn

Cheng's group focuses on the multifunctional nanomaterials for biomedical applications. The lab was founded in 2014. Cheng's lab is an energetic and creative team. We actively collaborate with international experts and scholars. Our group has set up the long-term collaboration with Prof. Maciej S. Lesniak, Director of Neurosurgery and Neuro-Oncology Research Center, Northwestern University of the United States, School of Medicine, National high-end foreign cooperation experts Prof. Gustavo Plaza from Madrid Polytechnic University, Spain, and Prof. Taro Uyeda from Waseda University of Japan. We provide a free and continued learning platform for everyone, create a world-class scientific research environment, and develop innovative research in Tongji University.

Education Background

2011 Ph.D. in Physical ChemistryCase Western Reserve University

2006 M.S. in Organic ChemistryWuhan University, Wuhan, P. R. China

2004 B.S. in Applied ChemistryWuhan University, Wuhan, P. R. China

Positions Held

2014-Present

Professor at School of MedicineTongji University, P. R. China

2011-2014

Postdoctoral Scholar at the Brain Tumor CenterThe University of Chicago, USA


Advanced materials for biomedical applications

Awards:

2015 1000Plan Professorship for Young Talents by the Chinese Government

2015 Pujiang Talents by Shanghai Government

2014 Chicago Biomedical Consortium Postdoctoral Research Award

2014 The University of Chicago 21st Annual Charles B. Huggins Symposium, Oral Presentation Award

2012 University of Chicago Biological Sciences Division Postdoc Association, Travel Award

2010 239th National American Chemical Society Meeting in Physical Chemistry Division, Outstanding Student Poster Award

2010 239th National American Chemical Society Meeting in Colloid and Surface Chemistry Division, Best Student Oral Presentation at the Biofunctional Architectures Symposium Session

2010 American Chemical Society Meeting-in-Miniature, Graduate Student Awardee

2010 Research ShowCASE Graduate Student Poster Contest, 2nd Prize

2009 The Microscopy Society of Northeastern Ohio Fall Meeting, 1st Place Graduate Physical Poster

2009 Research ShowCASE Graduate Student Poster Contest, 1st Prize

2008 Research ShowCASE Graduate Student Poster Contest, 1st Prize

2007 Research ShowCASE Graduate Student Poster Contest, Honorable Mention

2004 Excellent Undergraduate Thesis of Hubei Province, P.R.China

2003 Excellent Student of Wuhan University, Wuhan University

2002 Excellent Student of Wuhan University, Wuhan University

2001 Excellent Student of Wuhan University, Wuhan University


1Qishuai Feng, Yajing Shen, Yingjie Fu, Megan E. Muroski, Peng Zhang, Qiaoyue Wang, Chang Xu, Maciej S. Lesniak, Gang Li*, Yu Cheng*, “Self-Assembly of Gold Nanoparticles Shows Microenvironment-Mediated Dynamic Switching and Enhanced Brain Tumor Targeting”, Theranostics, 2017, 7(7), 1875-1889.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479275/

2Yajing Shen, Congyu Wu, Taro Q. P. Uyeda, Gustavo R. Plaza*, Bin Liu, Yu Han, Maciej S. Lesniak, and Yu Cheng*, “Elongated Nanoparticle Aggregates in Cancer Cells for Mechanical Destruction with Low Frequency Rotating Magnetic Field”, Theranostics, 2017, 7(6), 1735-1748.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436524/

3Yingjie Fu, Qishuai Feng, Yifan Chen, Yajing Shen, Qihang Su, Yinglei Zhang, Xiang Zhou *, Yu Cheng*, “Comparison of Two Approaches for the Attachment of a Drug to Gold Nanoparticles and Their Anticancer Activities”, Molecular Pharmaceutics 2016, 13,3308. http://pubs.acs.org/doi/abs/10.1021/acs.molpharmaceut.6b00619

4Ramin A. Morshed, Megan E. Muroski, Qing Dai, Michelle L. Wegscheid, Brenda Auffinger, Dou Yu, YuHan, Lingjiao Zhang, Meijing Wu, Yu Cheng*, Maciej S. Lesniak*. “Cell-Penetrating Peptide-Modified Gold Nanoparticles for the Delivery of Doxorubicin to Brain Metastatic Breast Cancer”, Molecular Pharmaceutics 2016, 13, 1843.http://pubs.acs.org/doi/abs/10.1021/acs.molpharmaceut.6b00004

5Megan E. Muroski, Ramin A. Morshed, Yu Cheng*, Tarun Vemulkar, Rodri, Mansell, Yu Han, Lingjiao Zhang, Karen S. Aboody, Russell P. Cowburn, Maciej S. Lesniak,* “Controlled Payload Release by Magnetic Field Triggered Neural Stem Cell Destruction for Malignant Glioma Treatment”, PLOS ONE, 2016, 11: e0145129.http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0145129

6Yu Cheng, Megan E. Muroski, Dorothee C.M.C. Petit, Rhodri Mansell, Tarun Vemulkar, Ramin A. Morshed, Yu Han, Irina V. Balyasnikova, Craig M. Horbinski, Xinlei Huang, Lingjiao Zhang, Russell Cowburn, Maciej S. Lesniak, "Rotating Magnetic Field Induced Oscillation of Magnetic Particles for in vivo Mechanical Destruction of Malignant Glioma", Journal of Controlled Release 2016, 223: 75.http://www.sciencedirect.com/science/article/pii/S0168365915302819

7Lijie Zhai, Kristen L. Lauing, Alan L. Chang, Mahua Dey, Jun Qian, Yu Cheng, Maciej S. Lesniak, Derek A. Wainwright, “The Role of IDO in Brain Tumor Immunotherapy”, Journal of Neuro-Oncology, 2015, 123,395. https://link.springer.com/article/10.1007/s11060-014-1687-8

8Hongying Liu, Tennyson L. Doane, Yu Cheng, Feng Lu, Shriya Srinivasana, Jun-Jie Zhu, Clemens Burda, “Control of Surface Ligand Density on PEGylated Gold Nanoparticles for Optimized Cancer Cell Uptake”, Particle and Particle Systems Characterization , 2015, 32, 197.http://onlinelibrary.wiley.com/doi/10.1002/ppsc.201400067/full

9Yu Cheng, Qing Dai, Ramin Morshed, Xiaobing Fan, Michelle L. Wegscheid, Derek A. Wainwright, Yu Han, Lingjiao Zhang, Brenda Auffinger, Alex L. Tobias, Esther Rincón, Bart Thaci, Atique U. Ahmed, Peter Warnke, Chuan He, Maciej S. Lesniak, “Blood-Brain Barrier Permeable Gold Nanoparticles: An Efficient Delivery Platform for Enhanced Malignant Glioma Therapy and Imaging ”, Small, 2014, 10, 513.http://onlinelibrary.wiley.com/doi/10.1002/smll.201400654/full

10Tennyson Doane, Yu Cheng, Nipun Sodhi, and Clemens Burda, “NIR Photocleavage of the SiC Bond in Axial Si-Phthalocyanines,The Journal of Physical Chemistry A, 2014, 118,10587.http://pubs.acs.org/doi/abs/10.1021/jp505656e

11Derek A. Wainwright, Alan L. Chang, Mahua Dey, Irina V. Balyasnikova, Chung Kwon Kim, Alex Tobias, Yu Cheng, Julius W. Kim, Jian Qiao, Lingjiao Zhang, Yu Han, Maciej S. Lesniak “Durable therapeutic efficacy utilizing combinatorial blockade against IDO, CTLA-4 and PD-L1 in mice with brain tumors”, Clin Cancer Res., 2015, 21,662http://clincancerres.aacrjournals.org/content/20/20/5290.short

12Yu Cheng, Tennyson L. Doane, Chi-Hung Chuang, Assem Ziady, Clemens Burda,“Near Infrared Light -Triggered Generation and Release of a Photodynamic Therapy Drug from Gold Nanoparticle Carriers”, Small, 2014, 10, 1799.http://onlinelibrary.wiley.com/doi/10.1002/smll.201303329/full

13Michelle M. Wegscheid, Ramin Morshed, Yu Cheng, Maciej S. Lesniak “The Art of Attraction: Applications of Multifunctional Magnetic Nanomaterials for Malignant Glioma”Expert Opin Drug Deliv. 2014, 11(6).http://www.tandfonline.com/doi/abs/10.1517/17425247.2014.912629

14Eun Ji Chung, Yu Cheng (共同第一作者), Ramin Morshed, Kathryn Nord, Yu Han, Michelle Wegscheid, Brenda Auffinger, Derek A. Wainwright, Maciej S. Lesniak, Matthew V. Tirrell. “Fibrin-Binding, Peptide Amphiphile Micelles for Targeting Glioblastoma”, Biomaterials, 2014, 35, 1249. http://www.sciencedirect.com/science/article/pii/S0142961213013082

15Yu Cheng, Ramin Morshed, Brenda Auffinger, Alex Tobias, Maciej S. Lesniak. “Multifunctional Nanoparticles for Brain Tumor Diagnosis and Therapy”, Adv. Drug Deliv. Rev. 2014, 66, 42. http://www.sciencedirect.com/science/article/pii/S0169409X1300201916Brenda Auffinger, Ramin Morshed, Alex L. Tobias, YuCheng, Atiqu e U. Ahmed, Maciej S. Lesniak. “Drug-Loaded Nanoparticle Systems and Adult Stem Cells: A Potential Marriage for the Treatment of Malignant Glioma?”, Oncotarget, 2013, 4, 378.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717302/

17Ramin Morshed, Yu Cheng, Brenda Auffinger, Michelle Wegscheid, Maciej Lesniak. “The potential of polymeric micelles in the context of glioblastoma multiforme therapy”, Frontiers of Pharmacology , 2013, 4, 157.

18Ramin Morshed, Yu Cheng, Brenda Auffinger, Michelle Wegscheid, Maciej Lesniak. “The potential of polymeric micelles in the context of glioblastoma multiforme therapy”, Frontiers of Pharmacology , 2013, 4, 157.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874582/

19Atique U. Ahmed, Bart Thaci, Alex L. Tobias, Brenda Auffinger, Lingjiao Zhang, Yu Cheng, Chung Kwon Kim, Catherine Yunis, Yu Han, Nikita G. Alexiades, Xiaobing Fan, Karen S. Aboody, Maciej S. Lesniak. “A Preclinical Evaluation of Neural Stem Cell-Based Cell Carrier for Targeted Antiglioma Oncolytic Virotherapy”, J. Natl. Cancer Inst. 2013, 105, 968.https://academic.oup.com/jnci/article/105/13/968/957480

20Yu Cheng, Ramin Morshed , Shih-Hsun Cheng, Alex Tobias, Brenda Auffinger, Derek A. Wainwright, Lingjiao Zhang, Catherine Yunis, Yu Han, Chin-Tu Chen, Leu-Wei Lo, Karen S. Aboody, Atique U. Ahmed, Maciej S. Lesniak. “Nanoparticle-Programmed Self-Destructive Neural Stem Cells for Glioblastoma Targeting and Therapy”, Small, 2013, 9, 4123.http://onlinelibrary.wiley.com/doi/10.1002/smll.201301111/full

21Brenda Auffinger, Bart Thaci, Pragati Nigam, Esther Rincon, Yu Cheng, Maciej S. Lesniak. “New Therapeutic Approaches for Malignant Glioma: In Search of the Rosetta Stone.” F1000 Medicine Report , 2012, 4, 18.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438652/

22Yu Cheng, Joseph D. Meyers, Ann-Marie Broome, Tennyson L. Doane, Malcolm E. Kenney, Clemens Burda, James P. Basilion “Addressing Brain Tumors with Targeted Gold Nanoparticles: A New Gold Standard for Hydrophobic Drug Delivery?”, Small, 2011, 7, 2301.http://onlinelibrary.wiley.com/doi/10.1002/smll.201100628/full

23Yu Cheng, Joseph D. Meyers, Ann-Marie Broome, Malcolm E. Kenney, James P. Basilion, Clemens Burda “Deep Penetration of a PDT Drug into Tumors by Noncovalent Drug-Gold Nanoparticle Conjugates”, J. Am. Chem. Soc. 2011, 133, 2583. http://pubs.acs.org/doi/abs/10.1021/ja108846h

24Yu Cheng, Clemens Burda “Nanoparticle-based Photodynamic Therapy”, Book Chapter of Comprehensive Nanoscience and Technology, 2010, Elsevier.

25Yu Cheng, Anna C. Samia, Jun Li, Malcolm E. Kenney, Andrew Resnick, Clemens Burda. “Delivery and Efficacy of a Cancer Drug as Function of the Bond to the Gold Nanoparticle Surface”, Langmuir 2010, 26, 2248http://pubs.acs.org/doi/abs/10.1021/la902390d

26Tennyson L. Doane, Yu Cheng, Amir Babar, Reghan J. Hill, Clemens Burda “Electrophoretic Mobilities of PEGylated Gold NPs”, J. Am. Chem. Soc. 2010, 132, 15624.http://pubs.acs.org/doi/abs/10.1021/ja1049093

27Yu Cheng, Anna C. Samia, Joseph D. Meyers, Irene Panagopoulos, Baowei Fei, Clemens Burda “Highly Efficient Drug Delivery with Gold Nanoparticle Vectors for in Vivo Photodynamic Therapy of Cancer” J. Am. Chem. Soc. 2008, 130, 10643.http://pubs.acs.org/doi/abs/10.1021/ja801631c


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