1) By revealing the molecular mechanism of ADSCs osteogenesis and the optimization of the induction scheme, the osteogenic induction of ADSCs was achieved. And it was found that ADSCs had low immunogenicity, and applying these discoveries to practice, such as the defect of the canine skull tissue was successfully repaired and the immune tolerance was achieved. It has solved the key problem of tissue engineering bone transition from clinical technology to clinical product by cryopreservation liquid researched by themselves.

2) Two kinds of ‘seed cells’ derived from ADSCs were provided for vascular tissue engineering through a joint induction system was established to successfully induce adipose stem cells to differentiate into vascular smooth muscle and endothelial cells respectively.

3) A small caliber (internal diameter <3mm ) smooth muscle lumen based on ADSCs has been successfully constructed in vitro by using a self-developed bioreactor. The lumen has excellent mechanical strength.

4) A new generation of polyglutamic peptide scaffolds have been developed, which have completed the repair of articular cartilage defects and the reconstruction of adipose tissue, which opened a new source of material for tissue engineering. And it lays the foundation for the development of materials with bone induced activity.

Bone tissue engineering based on ADSCs and corneal tissue engineering techniques based on oral mucosa epithelium have solved many problems for clinical practice.

Awards:

The second prize of The National Technology Invitation;

The second prize of the Ministry of Education;

The second prize of Shanghai Medical Technology.

The winner of ‘Dawn Scholar’ of Shanghai, ‘Excellent Subject Leaders of Shanghai’;

the National Excellent Teacher