The BMICL is devoted to tackling fundamental research challenges in multi-modality medical image analysis, biomechanics and mechanobiology and their clinical applications
Education Background
2013-2014, Professional Certificate in Teaching and Learning in Higher and Professional Education, Institute of Education, University of London.
2002-2005, Ph.D., Department of Engineering, University of Cambridge, UK.
1992-1998, MSc/PhD, Department of Mechanical Engineering, East China University of Science & Technology, P.R.China.
1988-1992, B.Sc. in Mechanical Engineering, Department of Mechanical Engineering, East China University of Science& Technology, P.R.China
Positions Held
2014-present,Professor of Biomedical Engineering, School of Medicine, Tongji University.
2009-2014, Research Associate, Centre for Medical Image Computing, Department of Computer Science, University College London.
2005-2009, Postdoctoral Research Associate, Cambridge Centre for Medical Materials, Department of Materials Science and Metallurgy, University of Cambridge.
2000-2002, Postdoctoral Research Assistant, Biomedical Image Analysis Laboratory, Institute of Biomedical Engineering, University of Oxford.
1998-2000, Postdoctoral Research Fellow, CAD Centre, INET, Tsinghua University.
Research focuses on biomechanics, mechanobiology, image-guided therapy and surgery, medical image analysis, as well as augmented reality. Specific areas of research topics include multi-modality image analyses for highly accurate cancer diagnosis, ultrasound-guided accurate prostate biopsy, ultrasound-guided breast-conserving surgery，multi-scale modeling of surgical wound healing and breast-conserving surgery simulation. Research is supported by 863, UK/EPSRC，EU FP7 and Shanghai Government. Our latest development involves in the development of an open-source finite element (FE) program for biomechanical modeling of soft tissues and a CE-marked medical device for ultrasound-guided prostate biopsy
Han L, Dong H., McClelland J. R., Han LX, Hawkes D J., and Barratt D. C., "A hybrid patient-specific biomechanical model based image registration method for the motion estimation of lungs," Medical Image Analysis 39, pp87-100, 2017. http://www.sciencedirect.com/science/article/pii/S1361841517300555.
Hipwell JH., Vasileios V., Han L.*, Mertzanidou T., Eiben B., and Hawkes D. J., "A review of biomechanically informed breast image registration," Physics in Medicine and Biology 61 (2), R1, 2016 (*Co-corresponding author). http://iopscience.iop.org/article/10.1088/0031-9155/61/2/R1/meta.
Johnsen S. F., Taylor Z. A., Han L., Hu Y., Clarkson M. J., Hawkes D. J., and Ourselin S., "Detection and modelling of contacts in explicit finite-element simulation of soft tissue biomechanics," International Journal of Computer Assisted Radiology and Surgery 10 (11), pp1873-1891, 2015. https://link.springer.com/article/10.1007/s11548-014-1142-5.
Han L., Hipwell J. H. , Eiben B., Barratt D., Modat M., Ourselin S., and Hawkes D. J. , "A nonlinear biomechanical model based registration method for aligning prone and supine MR breast images," IEEE Medical Imaging 33 (3), pp682-694, 2014. http://ieeexplore.ieee.org/document/6680759/
Mertzanidou T., Hipwell J., Johnsen S., Han L., Eiben B., Taylor Z., Ourselin S, Huisman H., Mann R., Bick U., Karssemeijer N., and Hawkes D., "MRI to X-ray mammography intensity-based registration with simultaneous optimisation of pose and biomechanical transformation parameters," Medical Image Analysis 18 (4), pp674-683, 2014. http://www.sciencedirect.com/science/article/pii/S1361841514000358.
Han L, Hipwell J.H, Tanner C, Taylor Z, Mertzanidou T., Cardoso J., Ourselin S. and Hawkes D. J., "Development of patient-specific biomechanical models for predicting Large Breast Deformation," Physics in Medicine and Biology, 57, pp455-472, 2012. http://iopscience.iop.org/article/10.1088/0031-9155/57/2/455/meta .
Han L, Laity P., Cameron R. and Elliott J., "Density and plastic strain evaluations using small-angle X-ray scattering and Finite Element simulations for powder compacts of complex shape," Journal of Materials Science, 46 (18), pp5977-5990, 2011. https://link.springer.com/article/10.1007/s10853-011-5559-8
Laity P., Han L., Elliott J. and Cameron R., "Variations in compaction behaviour for tablets of different size and shape, revealed by small-angle X-ray scattering," Journal of Pharmaceutical Sciences, 99(10), pp4380-4389, 2010. https://www.sciencedirect.com/science/article/pii/S0022354915324515
Han L., Elliott J. A., et al., "A modified Drucker-Prager Cap model for die compaction simulation of pharmaceutical powders," International Journal of Solids and Structures 45(10), pp3088-3106, 2008. http://www.sciencedirect.com/science/article/pii/S0020768308000322.
Han L., Noble J.A. and Burcher M., "A novel ultrasound indentation system for measuring biomechanical properties of in vivo soft tissue," Ultrasound in Medicine and Biology 29(6), pp813-823, 2003. http://www.sciencedirect.com/science/article/pii/S0301562902007767
