1. New mechanism: Clarifying the complex, combined by the C type lectin receptor Dectin-1 downstream CARD9 molecules and RasGRF1 and H-Ras, can activate the ERK pathway, which is the new mechanism of immune response to antifungal infection
2. New model: Clarifying that C type lectin receptor, Dectin-2 and Dectin-3, form a heterogenous two polymer to identify fungal surface α-mannose to enhance the immune response
3. New regulation: The degradation of C type lectin receptor(including Dectin-2 and Dectin-3) by ubiquitination has been proved that related to cbl-b, one of ubiquitin-ligase enzymes, and clarifying the negative regulatory mechanism of the antifungal immune response of type C lectin receptor
Education Background
2001 baccalaureate, the Second Military Medical University
2008 doctorate, the Second Military Medical University
Positions Held
The professor of Phytophthora and pathogenic microorganism；
Doctoral tutor in Tongji University School of Medicine；
The leader of the project of fungal infection and molecular immunization
The PI of center for clinical transformation medicine in Shanghai Pulmonary Hospital affiliated Tongji University
（1） Innate immune recognition of fungi infection
（2） Immune response mechanism of fungi infection
（3） Immunoregulation mechanism of fungi infection
Awards:
The owner of the National Natural Science Outstanding Youth Science Foundation
1. Zhu LL, …, Lin X*, Jia XM*. E3 ubiquitin ligase Cbl-b negatively regulates C-type lectin receptor–mediated antifungal innate immunity. J Exp Med. 2016;213(8):1555-70. . (2016 IF=11.9)；http://jem.rupress.org/content/213/8/1555
2. Jia XM*,…, Lin X*. CARD9 mediates Dectin-1–induced ERK activation by linking Ras-GRF1 to H-Ras for antifungal immunity. J Exp Med. 2014; 211(11):2307-21. (2016 IF=11.9); http://jem.rupress.org/content/211/11/2307
3. Zhu LL,…, Jia XM*, Lin X*. C-Type Lectin Receptors Dectin-3 and Dectin-2 Form a Heterodimeric Pattern-Recognition Receptor for Host Defense against Fungal Infection. Immunity, 2013, 39(2): 324–334. (2016 IF=22.08); http://www.sciencedirect.com/science/article/pii/S1074761313002987
4. Zhao XQ,…, Jia XM*, Lin X*. C-type lectin receptor dectin-3 mediates trehalose 6,6'-dimycolate (TDM)-induced Mincle expression through CARD9/Bcl10/MALT1-dependent nuclear factor (NF)-κB activation. J Biol Chem. 2014; 289(43):30052-62. (2016 IF=4.258); http://www.jbc.org/content/289/43/30052
5. Deng Z,…, Jia XM, …, Xiao H. Tyrosine phosphatase SHP-2 mediates C-type lectin receptor-induced activation of the kinase Syk and anti-fungal TH17 responses. Nat Immunol. 2015 Jun;16(6):642-52. (2016 IF=19.381); http://www.nature.com/articles/ni.3155
6. Zhao X, …, Jia X, ..., Lin X. JNK1 negatively controls antifungal innate immunity by suppressing CD23 expression. Nat Med. 2017 Mar;23(3):337-346. http://www.nature.com/articles/nm.4260
