We have been focusing on the relationship of human tumors and nonsense-mediated RNA decay (NMD). We are the first to identify a mutated NMD gene common to adenosquamous carcinoma tumors, differing from other types of pancreatic cancer. The findings are published in Nature Medicine in May 2014. We further found NMD pathway is disrupted in inflammatory myofibroblastic tumors of lung, which is generally poorly understood. The findings are published in Journal of Clinical Investigation in June 2016. Both works were cooperated with respected professor Miles F. Wilkinson and his team at the Department of Reproductive Medicine, UCSD, USA.
Education Background
1993-98 Ph.D., (Molecular Biology), Kyoto University,
Kyoto, Japan.
1986-89 M.Sc., (Immunology), 2nd Military Medical
University, Shanghai, China.
1980-84 B.Sc., (Biology), Shanghai Education University,
Shanghai, China.
Post-Doctoral Training:
1998-2000 Postdoctoral Fellow, Radiation Research Center, Kyoto University, Kyoto, Japan.
Positions Held
2007- Professor, Tongji university, Shanghai, China.
2000- 2007 Senior Scientist, Shanghai Celstar institute
of Biotechnology, Shanghai, China.
1989-1992 Lecture, 2nd Military Medical University,
Shanghai, China
The relationship of human tumors and nonsense-mediated RNA decay (NMD). NMD plays important roles in the messenger RNA (mRNA) quality control mechanism by eliminating faulty or undesired molecules that help transcribe genetic information into the construction of proteins. Loss of NMD in cells may release the brakes on these molecules, and thereby driving the cell growth and spread.
