The expanding global epidemic of obesity has become a major threat to human health. As the biggest drug targets, G protein coupled receptors (GPCRs) play an important role in the regulation of obesity-associated disease such as inflammation and insulin resistance. Our research focuses on the regulation of obesity-induced metabolic diseases by GPCR signal pathway.
Education Background
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Positions Held
2015-now professor School of Medicine, Tongji University
2009-2015 Research associate at Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA92037 (Advised by Professor Marc Montminy, member of the National Academy of Sciences, USA)
2003-2009 Ph.D. in Cell Biology Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences Shanghai, P. R. China (Advised by Professor Gang Pei, chief scientist and academician of the Chinese Academy of Sciences)
1999-2003 B.S. magna cum laude in Biology School of life science, Fudan University, Shanghai, P. R. China
Our research focuses on the regulation of obesity-induced metabolic diseases by GPCR signal pathway. Our works have unveiled the importance of β-arrestins and cAMP signal pathway in modulating glucose and lipid metabolism as well as inflammation-induced insulin resistance in metabolic tissues, which provide new mechanisms for the progress of type 2 diabetes and indicate new therapeutic targets for the treatment of the disease.
We will expand our research to the regulation of adipose tissue browning by GPCR and try to identify new targets for the treatment of obesity-associated diseases.
Awards:
2006 Liu yonglin scholarship
2007 Fudan Tanjiazhen-jiuyuan scholarship
2009 Chinese Academy of Science Presidential Scholarship (Special Prize)
2009 Meiji Life Science Award
2010 Excellent Doctoral Dissertation of Chinese Academy of Sciences
2010 The Excellent Doctoral Dissertation of Shanghai Municipality, China
2010 Helmsley Postdoctoral Fellows (Salk Institute)
2011 National Excellent Doctoral Dissertation Award nomination
2015 1000 Talents Program for Young Scholars of China
1. Glucagon-induced extracellular cAMP regulates hepatic lipid metabolism
Sihan Lv, Xinchen Qiu, Jian Li, Jinye Liang, Weida Li, Chao Zhang, Zhen-Ning Zhang, Bing Luan. Journal of Endocrinology: 2017 ,234 ,73
2. A negative feedback loop of ICER and NF-κB regulates TLR signaling in innate immune responses
Sihan Lv, Jian Li, Xinchen Qiu, Weida Li, Chao Zhang, Zhen-Ning Zhang and Bing Luan. Cell Death & Differentiation: 2016 ,doi:10.1038/cdd.2016.148
3. Suppression of CRTC2-mediated hepatic gluconeogenesis by TRAF6 contributes to hypoglycemia in septic shock
Sihan Lv, Xinchen Qiu, Jian Li, Weida Li, Chao Zhang, Zhen-Ning Zhang, Bing Luan. Cell Discovery: 2016 ,2,16046
4. SIK2 regulates fasting-induced PPARα activity and ketogenesis through p300
Zhen-Ning Zhang, Lulu Gong, Sihan Lv, Jian Li, Xiaolu Tai, Wenqi Cao, Bing Peng, Shen Qu, Weida Li, Chao Zhang & Bing Luan. Scientific Reports: 2016 ,6 ,23317
5. CREB pathway links PGE2 signaling with macrophage polarization
Bing Luan*, Youngsil Yoon, John Le Lay, Klaus H. Kaestner, Susan Hedrick, Marc Montminy*. PNAS:2015 ,112 ,15642-15647
6. Leptin-Mediated Increases in Catecholamine Signaling Reduce Adipose Tissue Inflammation via Activation of Macrophage HDAC
Bing Luan, Mark O. Goodarzi, Naomi G. Phillips, XiuqingGuo, Yii-Der I. Chen, Jie Yao, Matthew Allison, Jerome I. Rotter, Reuben Shaw, Marc Montminy. Cell Metabolism: 2014 ,19 ,1058-1065
7. Deficiency of a β-Arrestin2 signal complex contributes to insulin resistance
Bing Luan, Jian Zhao, Haiya Wu, BaoyuDuan, Guangwen Shu, Xiaoying Wang, Dangsheng Li, WeipingJia, Jiuhong Kang, Gang Pei. Nature: 2009 ,457 ,1146-1149
8. β-Arrestin2 functions as a phosphorylation regulated suppressor of UV-induced NF-κB activation
Bing Luan, Zhenning Zhang, Yalan Wu, Jiuhong Kang, Gang Pei. EMBO Journal: 2005 ,24 ,4237-4246
9. Identification of β-Arrestin2 as a G Protein-Coupled Receptor-Stimulated Regulator of NF-кB Pathways.
Hua Gao, Yue Sun, Yalan Wu, Bing Luan, Yaya Wang, Bin Qu, Gang Pei.. Molecular Cell: 2004 ,14 ,303-317
