The research on the mechanism of aging and epigenetics, especially how DNA methylation (demethylation) affects aging, and screening the transformation of anti-aging active components by endemic plant resources
Education Background
1999-2003 Bachelor of Science in agronomy, Shihezi University
2003-2006 Master of Biochemistry and molecular biology, Shihezi University
2006-2010 Doctor of Biomedical Engineering, Tongji University
2007-2009 Co-culture doctor of Plant Science Department, University of California, riverside (UCR)
Positions Held
Doctoral tutor, Ph. D Liu Hailiang, the vice professor of Tongji University School of Medicine; the leader of the Youth Research Group and Research Group on the center of stem cell clinical transformation, Tongji Hospital affiliated Tongji University; the director of the branch research and application of stem cells, Chinese Association of Plastic and Aesthetics
The epigenetic mechanism of stem cells(mesenchymal stem cells, neural stem cells) is used to study the occurrence and development of senescence(human, monkey and mouse) and the pathogenesis of neurodegenerative diseases associated with aging.
Awards:
2005 Scientific research innovation award, Shihezi University
2006 Excellent master's degree thesis, Shihezi University
2010 the Star of Epigenetics, Tongji University
2011 the Second prize in science and technology progress, Xinjiang production and construction corps.
Excellent doctor’s degree thesis, Tongji University
Youth Outstanding Talents Culture Plan, Tongji University
2012 Young talent – Outstanding Youth cultivation plan, Tongji University
2014 The first prize of Shanghai medical science and technology progress
1. Yongchang Chen, Juehua Yu, Yuyu Niu, Dongdong Qin, Hailiang Liu (Co-first author), et al. Modeling Rett Syndrome Using TALEN-Edited MECP2 Mutant Cynomolgus Monkeys, Cell, 2017, 169:1-11.
2. Hailiang Liu, Yongchang Chen, Yuyu Niu, et al. TALEN-Mediated Gene Mutagenesis in Rhesus and Cynomolgus Monkeys, Cell Stem Cell, 2014, 14: 323-328.
3. Gao Zhihuan, Liu Hai-Liang (Co-first author), Daxinger Lucia, et al. An RNA polymerase II- and AGO4-associated protein acts in RNA-directed DNA methylation, Nature, 2010, 465:106-118.
4. Jiansheng Guo, Hailiang Liu (Co-first author), Yangyang He, et al. Origination of asexual plantlets in three species of Crassulaceae, Protoplasma, 2015, 252 (2):591-603.
5. Jiang, Fangwei, Zhu, Jian, Liu, Hai-Liang (Corresponding author). Protoplasts: a useful research system for plant cell biology, especially dedifferentiation, Protoplasma, 2013, 250 (6):1231-1238.
6. HAI-LIANG LIU, HAI-TAO SHEN, CHEN CHEN, XUE-RONG ZHOU, HAIFENG LIU(*), JIAN-BO ZHU, Identification of a putative stearoyl acyl-carrier-protein desaturase gene from Saussurea involucrata kar. et kir, Biologia Plantarum, 2015, 59 (2): 316-324.
7. Fangwei Jiang, Zhenhua Feng, Hailiang Liu * (Co-corresponding author) , Jian Zhu * Involvement of Plant Stem Cells or Stem Cell-Like Cells in Dedifferentiation, Front Plant Sci, 2015, doi: 10.3389/fpls.2015.01028.
8. Fangwei Jiang, Xiaofeng Xu, Hailiang Liu* (Co-corresponding author), Jian Zhu*, DRM1 and DRM2 are involved in Arabidopsis callus formation, Plant Cell, Tissue and Organ Culture, 2015, 123:221–228.
9. Yuping Luo, Volkan Coskun, Aibing Liang, … Hailiang Liu, et al. Single cell transcriptome analyses reveal signals to activate dormant neural stem cells, Cell, 2015, 161(5):1175-1188.
10. He Xin-Jian, Hsu Yi-Feng, Zhu Shihua,… Liu Hai-Liang, et al. An Effector of RNA-Directed DNA Methylation in Arabidopsis Is an ARGONAUTE 4-and RNA-Binding Protein, Cell, 2009, 137 (3) :498-508.（
11. Honglin Qiu, Linhua Zhang, Chao Liu,…Hailiang Liu (Co-corresponding author) JianBo Zhu(*), Cloning and characterization of a novel dehydrin gene, SiDhn2, from Saussurea involucrata Kar. et Kir, Plant Molecular Biology, 2014, 84 (6): 707-718.
12. Liu Hai-liang, Wang Guang-Chao, Feng Zhenhua, Zhu Jian(*) ,Screening of genes associated with dedifferentiation and effect of LBD29 on pericycle cells in Arabidopsis thaliana, Plant Growth Regulation, 2010, 62 (2): 127-136.
13. He Xin-Jian, Hsu Yi-Feng, Zhu Shihua, Liu Hai-Liang, et al. A conserved transcriptional regulator is required for RNA-directed DNA methylation and plant development, Genes & Development, 2009, 23 (23): 2717-2722.
