The main research focuses on the development and function of cardiovascular and conduction systems, the development and function of the cardiac stem cells and peripheral nervous system.
Education Background
1991.09-1995.07: Education and work experience: Chinese Academy of Medical Sciences, doctor of medicine. Graduate in advance.
1996.07-2001. 05: Institute of biotechnology, University of Helsinki, Finland.
2001.05-2002.10: The Harvard Medical Institute, Harvard University, postdoctoral fellow and research scientist.
Department of medicine, University of California at San Diego:
2002.10-2004.07, postdoctoral fellows research fellow;
2004.07-2010.07 research assistant professor (scientist);
2010.07-2011.01 Research Associate Professor, through the American doctor qualification test.
2011.01 to present the Department of pathophysiology, Tongji University medical school, Key Laboratory of arrhythmia Department of education, Tongji University, affiliated to the Eastern Hospital Medical transformation platform, Professor, master's master's tutor, PI
Positions Held
1. The national natural fund project assessment expert.
2. Jiangsu science and technology progress award evaluation expert.
3. Expert on budgetary evaluation of major science and technology
1. The cardiac and pacing system, as well as the regulation mechanism of the development and function of blood vessels.
2. Translational medical study of cardiac regeneration
1) The genealogical origin of cardiac cells and its role in the formation of different cardiac structures and its regulatory mechanism
2) The formation and regulation mechanism of cardiac pacemaker
3) The formation and regulation mechanism of peripheral nervous system
Focus on gene function and molecular regulation and its transformation in congenital heart disease, arrhythmia, and heart regeneration.
3. Vascular formation regulation mechanism and vascular disease
Clarify the interaction of cell and signal mediated by integrin signaling pathway:
1) The mechanism of action in vascular endothelial cells
2) The mechanism of action in vascular smooth muscle
3) How to mediate the interaction of vascular cells
Awards:
1. excellent doctoral student of Union Medical College, Chinese Academy of Medical Sciences
2. members of the international otorhinolaryngology Association
3. Schulman prize for outstanding cardiovascular research in California University
4. Tongji University affiliated oriental hospital research contribution award
5. national innovation research group science team award
6. Shanghai Pujiang talent plan
7. 2017 Year Award for the top ten tutors at the Tongji University medical school
8. 2017 Year Second Award for the outstanding papers of Pudong New Area.
1. Xingqun Liang, Sylvia M. Evans, Yunfu Sun. Development of the cardiac pacemaker. Cellular Biology Life Science. (2017) 74:1247–1259. 通讯作者
2. Ye M, Zhang Q, Xu X, Zhang Q, Ge Y, Geng P, Yan J, Luo L, Sun Y, Liang X. Loss of JAM-C leads to impaired esophageal innervations and megaesophagus in mice. Diseases of the Esophagus. (2016) 29, 864–871. 通讯作者
3. Tommi Anttonen, … Xingqun Liang, Ulla Pirvola. c-Jun N-Terminal Phosphorylation: Biomarker for Cellular Stress Rather than Cell Death in the Injured Cochlea1,2,3. eNeuro. 2016 Mar-Apr, Published online.
4. Liang X*, Zhang Q, Cattaneo P, Zhuang S, Gong X, Spann NJ, Jiang C, Cao X, Zhao X, Zhang X, Bu L, Wang G, Chen HS, Zhuang T, Yan J, Geng P, Luo L, Banerjee I, Chen Y, Glass CK, Zambon AC, Chen J, Sun Y, Evans SM. Isl1 Is an Essential Regulator of Pacemaker Development and Function. J Clin Invest. 2015 Aug 3; 125(8):3256-68. 通讯作者
5. Liang X, Evans SM, Sun Y. Insights into Cardiac Conduction System Formation Provided by HCN4 Expression. Trends in Cardiovascular Medicine. 2015，25(1)：1-9
6. Mastrototaro G, Liang X, Li X, Carullo P, Piroddi N, Tesi C, Gu Y, Dalton ND, Peterson KL, Poggesi C, Sheikh F, Chen J, Bang ML. Nebulette knockout mice have normal cardiac function, but showZ-line widening and up-regulation of cardiac stress markers. Cardiovasc Res. 2015 Jul 15;107(2):216-25. doi: 10.1093/cvr/cvv156. Epub 2015 May 17 第一作者
7. Dai X, Jiang W, Zhang Q, Xu L, Geng P, Zhuang S, Petrich BG, Jiang C, Peng L, Bhattacharya S, Evans SM, Sun Y, Chen J, Liang X*. Requirement for integrin-linked kinase in neural crest migration and differentiation and outflow tract morphogenesis. BMC Biol. 2013 Oct 16; 11:107. 通信作者
8. Zhuang S, Zhang Q, Zhuang T, Evans SM, Liang X*, Sun Y. Expression of Isl1 during mouse development. Gene Expr Patterns. 2013 Jul 29;13(8):407-412. 通信作者
9. Liang X, Wang G, Lin L, Lowe J, Zhang Q, Bu L, Chen Y, Chen J, Sun Y*, Evans SM*. HCN4 Dynamically Marks the First Heart Field and Conduction System Precursors. Circ Res. 2013 Aug 2;113(4):399-407. Epub 2013 Jun 6.
10. Liang X, Song MR, Xu Z, Lanuza GM, Liu Y, Zhuang T, Chen Y, Pfaff SL, Evans SM, Sun Y. Isl1 Is required for multiple aspects of motor neuron development. Mol. Cell. Neurosci. 2011 April 26;8-15.
11. Ye M, Coldren C, Liang X, Mattina T, Goldmuntz E. Benson W, Ivy D, Perryman MB, Garrett-Sinha LA, Grossfeld P. Deletion of ETS-1, a gene in the Jacobsen syndrome critical region, causes ventricular septal defects in mice. Human Molecular Genetics. 2010;19:648.
12. Liang X, Sun YF and Chen J. Particularly Interesting Cysteine- and Histidine-Rich Protein in Cardiac Development and Remodeling. J Investig Med. 2009 Dec 57(8):842-8.
13. Liang XQ, Sun YF, Yi MQ, Paul H Evans SE and Ju Chen. Inactivation of PINCH1 and PINCH2 Disrupts Cardiomyocytes Focal Adhesion, Resulting in Cardiomyopthy and Heart Failure. Circulation. 2009 Aug 18; 120(7):568-76. Epub 2009 Aug 3.
14. Sun YF, Dykes IM, Liang XQ, Eng SR, Evans SM, Turner EE. A central role for Islet1 in sensory neuron development linking sensory and spinal gene regulatory programs. Nat Neurosci. 2008 Nov; 11(11):1283-93. Epub 2008 Oct 12.
15. Cai CL, Martin JC, Sun Y, Cui L, Wang L, Ouyang K, Yang L, Bu L, Liang X, Zhang X, Stallcup WB, Denton CP, McCulloch A, Chen J, Evans SM. A myocardial lineage derives from Tbx18 epicardial cells. Nature, 2008 Jul 3; 454(7200):104-8.
16. Sheikh F, Raskin A, Chu PH, Lange S, Domenighetti AA, Zheng M, Liang X, Zhang T, Yajima T, Gu Y, Dalton ND, Mahata SK, Dorn GW 2nd, Heller-Brown J, Peterson KL, Omens JH, McCulloch AD, Chen J. An FHL1-containing complex within the cardiomyocyte sarcomer mediates hypertrophic biomechanical stress response in mice. J Clin Invest. 2008;118:3870
17. Sun Y, Liang X*, Najafi N, Cass M, Lin L, Cai CL, Chen J, and Evans SM. Islet 1 is expressed in distinct cardiovascular lineages, including pacemaker and coronary vascular cells. Dev Biol. 2007; 304(1):286-96. (*equal contribution)
18. Liang X, Sun Y, Schneider J, Ding JH, Cheng H, Ye M, Bhattacharya S, Rearden A, Evans S, Chen J. Pinch1 is required for normal development of cranial and cardiac neural crest-derived structures. Circ Res. 2007; 100(4): 527-535.
19. Sun YF, Liang XQ*, and Evans SM. (2007). Islet1 Progenitors in Developing and Postnatal Heart. Cardiovascular Development (ADB series). (*equal contribution)
20. Sheikh F, Chen TH, Liang X, Hirschy A, Stenbit AE, Gu Y, Dalton NE, Yajima T, Lu YC, Fusch E, Knowlton KU, Peterson KL, Perriard JC and Chen J. alpha-E-Catenin Inactivation Disrupts the Cardiomyocyte Adherens Junction Resulting in Cardiomyopathy and Susceptibility to Wall Rupture. Circulation. 2006; 114: 1046-55.
21. Liang X, Zhou Q, Li X, Sun Y, Lu M, Dalton N, Ross J Jr, and Chen J. PINCH1 plays an essential role in early murine embryonic development but is dispensable in ventricular cardiomyocytes. Mol Cell Biol. 2005; 25(8):3056-62
22. Cai CL, Liang X, Shi Y, Chu PH, Pfaff SL, Chen J, and Evans SM. Isl1 Identifies a Cardiac Progenitor Population that Proliferates Prior to Differentiation and Contributes a Majority of Cells to the Heart. Dev Cell. 2003; 5:877
23. Liang X, Hava Avraham, Shuxian Jiang, Tae-Aug Kim, and Shalom Avraham . Genetic alterations of NRP/B gene associated with human brain tumors. Cancer Res 2004; 23: 5890-5900.
Book Chapters：
1. Yunfu Sun, Liang X, and Sylvia Evans. (2007). Islet1 Progenitors in Developing and Postnatal Heart Cardiovascular Development. Advance in Developmental Biology. 2008 (18): 154-65.
Shalom Avraham, Hava Avraham, Shuxian Jiang, Xia Bu, Liang X, Seyha Seng and Tae-Aug Kim (2002). The superfamily of proteins containing Kelch and/or BTB domains: From cytoskeleton dynamics to transcriptional regulation. Recent Res. Devel. Bio. Chem. (Review, book). 1:231-254.
