The basic research on the malignant infectious diseases such as malaria and schistosomiasis was mainly carried out by Zhang Qingfeng project group. They use a variety of molecular / cellular biology technology platform, combined with efficient genome editing system and high-throughput protein / nucleic acid analysis technology, explored the interaction between pathogen and host as well as the molecular mechanism of its pathogenicity. On this basis, they screened and identified new key molecular targets associated with diagnosis, prevention and treatment.
Education Background
1. Graduated from Biochemistry Engineering Department of Zhejiang University
2. Got master's degree and doctor's degree of pathogen biology from Second Military Medical University and Tongji University respectively
Positions Held
1. The professor and doctoral supervisor of Department of immunology and pathogenic biology
2. The head of the subject of the center for transformation medicine, Eastern Hospital Affiliated to Tongji University.
(1) Molecular mechanism of Plasmodium falciparum antigen variation and immune evasion；
(2) Study on genome editing and functional genomics of Plasmodium falciparum；
(3) The growth and development of Schistosoma japonicum and the mechanism of its interaction with its host;
(4) Functional genomics of Schistosoma japonicum;
Awards: -
. Zhao J, Luo R, Xu X, Zou Y, Zhang Q*, Pan W*. High-throughput sequencing of RNAs isolated by cross-linking immunoprecipitation (HITS-CLIP) reveals Argonaute-associated microRNAs and targets in Schistosoma japonicum. Parasites & Vectors. 2015；8(1):589. （https://parasitesandvectors.biomedcentral.com/articles/10.1186/s13071-015-1203-9）
2. Wei G, Zhao Y, Zhang Q*, Pan W*. Dual regulatory effects of non-coding GC-rich elements on the expression of virulence genes in malaria parasites. Infection, Genetics and Evolution. 2015, 36:490-9. (http://www.sciencedirect.com/science/article/pii/S1567134815003469?via%3Dihub)
3. Zhang Q*, Scherf A*. RNase II: A new player enters the game. RNA Biology. 2015; 12(6):586-9. （http://www.tandfonline.com/doi/full/10.1080/15476286.2015.1038013）
4. Zhang Q*, Siegel TN, Martins RM, Wang F, Cao J, Gao Q, Cheng X, Jiang L, Hon CC, Scheidig-Benatar C, Sakamoto H, Turner L, Jensen AT, Claes A, Guizetti J, Malmquist NA, Scherf A*. Exonuclease-mediated degradation of nascent RNA silences genes linked to severe malaria. Nature. 2014，513(7518):431-5.（http://www.nature.com/nature/journal/v513/n7518/full/nature13468.html）
6. Zhang Y, Yan H, Wei G, Han S, Huang Y, Zhang Q*, Pan W*. Distinctive origin and spread route of pyrimethamine-resistant Plasmodium falciparum in southern China. Antimicrobial Agents and Chemotherapy. 2014, 58(1):237-46. (http://aac.asm.org/content/58/1/237.long)
7. Cheng Q, Zhang Q, Xu X, Yin L, Sun L, Lin X, Dong C, Pan W. MAPK Phosphotase 5 Deficiency Contributes to Protection against Blood-Stage Plasmodium yoelii 17XL Infection in Mice. Journal of Immunology. 2014, 192 (8):3686-96.（http://www.jimmunol.org/content/192/8/3686.long）
8. Jiang L, Mu J, Zhang Q, Ni T, Srinivasan P, Rayavara K, Yang W, Turner L, Lavstsen T, Theander TG, Peng W, Wei G, Jing Q, Wakabayashi Y, Bansal A, Luo Y, Ribeiro JM, Scherf A, Aravind L, Zhu J, Zhao K, Miller LH. PfSETvs methylation of histone H3K36 represses virulence genes in Plasmodium falciparum. Nature. 2013, 499(7457):223-7. （http://www.nature.com/nature/journal/v499/n7457/full/nature12361.html）
9. Zhang Q, Huang Y, Zhang Y, Fang X, Claes A, Duchateau M, Namane A, Lopez-Rubio JJ, Pan W, Scherf A. A Critical Role of Perinuclear Filamentous Actin in Spatial Repositioning and Mutually Exclusive Expression of Virulence Genes in Malaria Parasites. Cell Host & Microbe. 2011, 10 (5):451-63. （http://www.sciencedirect.com/science/article/pii/S1931312811003325?via%3Dihub）
10. Zhang Q, Zhang Y, Huang Y, Xue X, Yan H, Sun X, Wang J, McCutchan TF, Pan W. From in vivo to in vitro: dynamic analysis of Plasmodium falciparum var gene expression patterns of patient isolates during adaptation to culture. PLoS One. 2011, 6 (6):e20591. （http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0020591）
11. Mancio-Silva L, Zhang Q, Scheidig-Benatar C, Scherf A. Clustering of dispersed ribosomal DNA and its role in gene regulation and chromosome-end associations in malaria parasites. Proc Natl Acad Sci U S A. 2010, 107(34):15117-22. （http://www.pnas.org/content/107/34/15117.long）
